Association of estrogen receptor α gene polymorphism with the presence of coronary artery disease documented by coronary angiography

被引:26
作者
Boroumand, Mohammadah
Ghaedi, Mahboubeh [2 ]
Mohammadtaghvaei, Narges [2 ]
Pourgholi, Leila
Anvari, Maryam Sotoudeh
Davoodi, Gholamreza
Amirzadegan, Alireza
Saadat, Soheil [3 ]
Sheikhfathollahi, Mahmood [1 ]
Goodarzynejad, Hamidreza [4 ]
机构
[1] Univ Tehran Med Sci, Tehran Heart Ctr, Dept Biostat, Tehran, Iran
[2] Tarbiat Modares Univ, Fac Med, Dept Clin Biochem, Tehran, Iran
[3] Univ Tehran Med Sci, Sina Trauma & Stagety Res Ctr, Tehran, Iran
[4] Univ Tehran Med Sci, Tehran Heart Ctr, Res Dept, Tehran, Iran
关键词
Estrogen receptor; Coronary artery disease; Iranian population; DENSITY-LIPOPROTEIN CHOLESTEROL; HORMONE REPLACEMENT THERAPY; MYOCARDIAL-INFARCTION; RISK; SEVERITY; MEN; GENOTYPE; HEALTHY; CLONING; WOMEN;
D O I
10.1016/j.clinbiochem.2009.01.005
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
100118 [医学信息学]; 100208 [临床检验诊断学];
摘要
Objectives: To examine the relationship between Pvull and Xbal polymorphisms, with the presence of angiographically determined CAD in an Iranian population. Design and methods: Patients having angiographic evidence of atherosclerosis (Gensini score>6) in their epicardial coronary tree (CAD(+) case group) were compared with Patients with Gensini score <= 6 (CAD(-) control group). The presence of Pvull and Xbal polymorphisms was analyzed using polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Results: The Pvull genotype distributions were not statistically different in CAD groups, and subgroups stratified by gender. For the Xbal polymorphism, after controlling for age, male sex, cigarette smoking and hyperlipidemia, Xbal GG genotype was not also found to be an independent predictor for CAD occurrence (OR=1.65; 95% CI: 0.90-3.03; P=0.10). Conclusions: We did not observe an association between ESR1 Pvull and Xbal gene polymorphisms with CAD in the risk of CAD in an Iranian population. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:835 / 839
页数:5
相关论文
共 34 条
[1]
Estrogen receptor 1 gene polymorphisms and coronary artery disease in the Brazilian population [J].
Almeida, S ;
Hutz, MH .
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2006, 39 (04) :447-454
[2]
Correlation between lipoprotein(a) serum concentration and severity of coronary artery stenosis in an Iranian population according to Gensini score [J].
Boroumand, Mohammad All ;
Rekabi, Vahab ;
Davoodi, Gholamreza ;
Amirzadegan, Alireza ;
Saadat, Soheil ;
Abbasi, Seyed Hesameddin ;
Hamidian, Reza ;
Poorgholi, Leila .
CLINICAL BIOCHEMISTRY, 2008, 41 (03) :117-120
[3]
Estrogen receptor-α polymorphisms and angiographic outcome after coronary artery stenting [J].
Ferrero, V ;
Ribichini, F ;
Matullo, G ;
Guarrera, S ;
Carturan, S ;
Vado, A ;
Vassanelli, C ;
Piazza, A ;
Uslenghi, E ;
Wijns, W .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (12) :2223-2228
[4]
FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
[6]
Mechanisms of disease - Production and actions of estrogens [J].
Gruber, CJ ;
Tschugguel, W ;
Schneeberger, C ;
Huber, JC .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (05) :340-352
[7]
Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein [J].
Herrington, DM ;
Howard, TD ;
Brosnihan, KB ;
McDonnell, DP ;
Li, XL ;
Hawkins, GA ;
Reboussin, DM ;
Xu, JF ;
Zheng, SQL ;
Meyers, DA ;
Bleecker, ER .
CIRCULATION, 2002, 105 (16) :1879-1882
[8]
Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. [J].
Herrington, DM ;
Howard, TD ;
Hawkins, GA ;
Reboussin, DM ;
Xu, JF ;
Zheng, SL ;
Brosnihan, KB ;
Meyers, DA ;
Bleecker, ER .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (13) :967-974
[9]
Estrogen receptor α is a major mediator of 17β-estradiol's atheroprotective effects on lesion size in Apoe-/- mice [J].
Hodgin, JB ;
Krege, JH ;
Reddick, RL ;
Korach, KS ;
Smithies, O ;
Maeda, N .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (03) :333-340
[10]
Estrogen receptor α polymorphism and risk of cardiovascular disease, cancer, and hip fracture -: Cross-sectional, cohort, and case-control studies and a meta-analysis [J].
Kjaergaard, Alisa D. ;
Ellervik, Christina ;
Tybjaerg-Hansen, Anne ;
Axelsson, Christen Kirk ;
Gronholdt, Marie-Louise M. ;
Grande, Peer ;
Jensen, Gorm B. ;
Nordestgaard, Borge G. .
CIRCULATION, 2007, 115 (07) :861-871