Association of estrogen receptor α gene polymorphism with the presence of coronary artery disease documented by coronary angiography

Objectives: To examine the relationship between Pvull and Xbal polymorphisms, with the presence of angiographically determined CAD in an Iranian population. Design and methods: Patients having angiographic evidence of atherosclerosis (Gensini score>6) in their epicardial coronary tree (CAD(+) case group) were compared with Patients with Gensini score <= 6 (CAD(-) control group). The presence of Pvull and Xbal polymorphisms was analyzed using polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Results: The Pvull genotype distributions were not statistically different in CAD groups, and subgroups stratified by gender. For the Xbal polymorphism, after controlling for age, male sex, cigarette smoking and hyperlipidemia, Xbal GG genotype was not also found to be an independent predictor for CAD occurrence (OR=1.65; 95% CI: 0.90-3.03; P=0.10). Conclusions: We did not observe an association between ESR1 Pvull and Xbal gene polymorphisms with CAD in the risk of CAD in an Iranian population. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.