Aberrant Expression of CD8 in B-Cell Non-Hodgkin Lymphoma

被引：29

作者：

Carulli, Giovanni ^{[1
,2
]}

Stacchini, Alessandra ^{[3
]}

Marini, Alessandra ^{[4
]}

Ciriello, Maria Matilde ^{[5
]}

Zucca, Alessandra ^{[1
,2
]}

Cannizzo, Elisa ^{[1
,2
]}

Aliberti, Sabrina ^{[3
]}

Demurtas, Anna ^{[3
]}

Novero, Domenico ^{[3
]}

Calcagno, Lara ^{[5
]}

Callegari, Tiziana ^{[5
]}

Petrini, Mario ^{[1
,2
]}

机构：

[1] Univ Pisa, Div Hematol, Dept Oncol Transplants & New Technol Med, Pisa, Italy

[2] Univ Pisa, Flow Cytometry Sect, Dept Oncol Transplants & New Technol Med, Pisa, Italy

[3] San Giovanni Battista Hosp, Flow Cytometry Unit, Pathol Lab, Turin, Italy

[4] Versilia Hosp, Clin Pathol Lab, Lido Di Camaiore, Italy

[5] SS Antonio & Biagio Hosp, Clin Pathol Lab, Alessandria, Italy

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2009年 / 132卷 / 02期

关键词：

CD8; Flow cytometry; Non-Hodgkin lymphoma; B-cell chronic lymphocytic leukemia; CHRONIC LYMPHOCYTIC-LEUKEMIA; IMMUNOGLOBULIN; ANTIGENS;

D O I：

10.1309/AJCPNCOHS92ARWRQ

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

T-cell antigen expression can be observed in B-cell non-Hodgkin lymphoma (B-NHL). Although CD5 is expressed in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma, the presence of other T-cell antigens is less common. This article reports a retrospective multicenter analysis in which flow cytometry was used to evaluate aberrant CD8 expression on the pathologic B cells of 951 bone marrow samples from patients with various types of B-NHL. In a total of 18 patients, CD8 was coexpressed: 10 had B-CLL; 1, small lymphocytic lymphoma (SLL); 1, marginal zone lymphoma; 1, lymphoplasmacytic lymphoma; 2, diffuse large B-cell lymphoma; and 3, follicular lymphoma. There was a 1.89% overall frequency of CD8 coexpression in which B-CLL/SLL had a higher frequency (3.03%) than did the other B-cell neoplasms (1.18%). Most cases were characterized by a favorable outcome.

引用

页码：186 / 190

页数：5

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