HIV type 1 strains from East and West Africa are intermixed in Sudan

被引：22

作者：

Hierholzer, M

Graham, RR

El Khidir, I

Tasker, S

Darwish, M

Chapman, GD

Fagbami, AH

Soliman, A

Birx, DL

McCutchan, F

Carr, JK

机构：

[1] Henry M Jackson Fdn, Rockville, MD 20850 USA

[2] USN, Virol Res Program, Med Res Unit 3, Cairo, Egypt

[3] Minist Hlth Sudan, Khartoum, Sudan

[4] USN, Med Res Ctr, Silver Spring, MD 20850 USA

[5] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2002年 / 18卷 / 15期

关键词：

D O I：

10.1089/088922202320567923

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The genetic subtypes of HIV-1 in the Sudan epidemic have not been characterized. Here we report the partial sequencing and analysis of 30 strains collected from HIV-1-positive patients and blood donors in Khartoum in 1998 and 1999. From analysis of partial pol and env sequences, it was determined that 50% were subtype D and 30% were subtype C. Of interest, some subtype D clustered with those from East Africa whereas others joined subtype D from West Africa. Subtype A, subtype B, and three unique recombinants were also found, some partially unclassifiable. One unclassified strain matched another reported previously from the Democratic Republic of Congo. Sudan borders nine other African countries, and has suffered more than 20 years of civil strife with large population displacements. The intermixing of HIV-1 subtypes previously separated in Africa may be occurring there, with the potential to generate novel new strains by recombination.

引用

页码：1163 / 1166

页数：4

共 9 条

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