Cytosporones, coumarins, and an alkaloid from the endophytic fungus Pestalotiopsis sp isolated from the Chinese mangrove plant Rhizophora mucronata

被引：99

作者：

Xu, Jing ^{[2
,3
]}

Kjer, Julia ^{[2
]}

Sendker, Jandirk ^{[2
]}

Wray, Victor ^{[4
]}

Guan, Huashi ^{[3
]}

Edrada, RuAngelie

Mueller, Werner E. G. ^{[6
]}

Bayer, Mirko ^{[2
]}

Lin, Wenhan ^{[1
]}

Wu, Jun ^{[5
]}

Proksch, Peter ^{[2
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Natl Res Labs Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany

[3] Ocean Univ China, Inst Marine Drugs & Food, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[4] Helmholtz Ctr Infect Res, Dept Biol Struct, D-38124 Braunschweig, Germany

[5] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China

[6] Johannes Gutenberg Univ Mainz, Inst Physiol Chem & Pathobiochem, D-55128 Mainz, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 20期

关键词：

Cytosporones; Coumarins; Alkaloid; Pestalotiopsis sp; Spectroscopic data analysis; METABOLITES; CYCLOHEXENONE; MICROSPORA; ANTIFUNGAL; TAXOL; ACID;

D O I：

10.1016/j.bmc.2009.08.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical examination of the endophytic fungus Pestalotiopsis sp., isolated from the leaves of the Chinese mangrove Rhizophora mucronata, yielded 11 new compounds including cytosporones J-N (1-3, 5-6), five new coumarins pestalasins A-E (8-12), and a new alkaloid named pestalotiopsoid A (14), along with the known compounds cytosporone C (4), dothiorelone B (7), and 3-hydroxymethyl-6,8-dimethoxycoumarin (13). The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic data analysis. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：7362 / 7367

页数：6

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