Eicosanoids and the stomach

被引：33

作者：

Atay, S

Tarnawski, AS

Dubois, A

机构：

[1] Vet Adm Med Ctr, Gastroenterol Sect, Long Beach, CA 90822 USA

[2] Uniformed Serv Univ Hlth Sci, Gastrointestinal & Liver Studies Lab, Bethesda, MD 20814 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2000年 / 61卷 / 3-4期

关键词：

eicosanoids; stomach; secretion; motility; emptying; gastroprotection; mucosal defense; apoptosis;

D O I：

10.1016/S0090-6980(00)00067-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eicosanoids are arachidonic acid derivatives that include prostaglandins, thromboxanes, and leukotrienes. During the last three decades, it has become evident that these bioactive Lipids play a pivotal role in gastric physiology. The goal of the present review is to describe their involvement in the normal regulation of gastric secretion and gastric motility, as well as in gastric mucosal defense. Their role in gastric mucosal mitogenesis, apoptosis, inflammation, and immune modulatory responses is also discussed. (C) 2000 Published by Elsevier Science Inc. All rights reserved.

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页码：105 / 124

页数：20

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