Collagen fibrils: Nanoscale ropes

被引:190
作者
Bozec, Laurent
van der Heijden, Gert
Horton, Michael
机构
[1] UCL, Bone & Mineral Ctr, Dept Med, London WC1E 6JJ, England
[2] UCL, Dept Civil & Environm Engn, London WC1E 6JJ, England
[3] London Ctr Nanotechnol, London, England
基金
英国惠康基金;
关键词
D O I
10.1529/biophysj.106.085704
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The formation of collagen fibrils from staggered repeats of individual molecules has become "accepted'' wisdom. However, for over thirty years now, such a model has failed to resolve several structural and functional questions. In a novel approach, it was found, using atomic force microscopy, that tendon collagen fibrils are composed of subcomponents in a spiral disposition-that is, their structure is similar to that of macroscale ropes. Consequently, this arrangement was modeled and confirmed using elastic rod theory. This work provides new insight into collagen fibril structure and will have wide application-from the design of scaffolds for tissue engineering and a better understanding of pathogenesis of diseases of bone and tendon, to the conservation of irreplaceable parchment-based museum exhibits.
引用
收藏
页码:70 / 75
页数:6
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