Arenes to anilines and aryl ethers by sequential iridium-catalyzed borylation and copper-catalyzed coupling

被引：142

作者：

Tzschucke, C. Christoph

Murphy, Jaclyn M.

Hartwig, John F.

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 05期

关键词：

D O I：

10.1021/ol062902w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Alkyl- and N-arylanilines were synthesized from arenes by a two-step sequence of iridium-catalyzed borylation and copper-catalyzed coupling with amines. Diaryl ethers were obtained by a related sequence of arene borylation, followed by coupling with phenols. In particular, 3,5-disubstituted arylamines and aryl ethers were prepared by initiating this sequence with meta-substituted arenes.

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页码：761 / 764

页数：4

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