Leptin signalling

被引：288

作者：

Sweeney, G ^{[1
]}

机构：

[1] York Univ, Dept Biol, N York, ON M3J 1P3, Canada

来源：

CELLULAR SIGNALLING | 2002年 / 14卷 / 08期

关键词：

obesity; JAK/STAT; SOCS; SHP2; PI; 3-kinase; MAP kinase; PKC; phosphodiesterase; nitric oxide;

D O I：

10.1016/S0898-6568(02)00006-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The identification of leptin as the product of the obesity (ob) gene has been followed by extensive research identifying a wide spectrum of physiological effects elicited by this adipose-derived hormone. These effects are mediated via a family of cytokine-like receptor isoforms distributed in both the central nervous system and periphery. The signal transduction pathways regulated by leptin are diverse and include those characteristic of both cytokine and growth factor receptor signalling. This review describes the structure and function of leptin receptors and summarizes recent progress that has been made in characterizing the increasing number of signal transduction pathways regulated by leptin. (C) 2002 Elsevier Science Inc. All rights reserved.

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收藏

页码：655 / 663

页数：9

相关论文

共 120 条

[1] Leptin [J].

Ahima, RS ;

Flier, JS .

ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 :413-437

[2]

AHREN B, 1992, AM J PHYSIOL, V277, pR959

[3] Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, Rho-, and Rac-dependent signaling pathways [J].

Attoub, S ;

Noe, V ;

Pirola, L ;

Bruyneel, E ;

Chastre, E ;

Mareel, M ;

Wymann, MP ;

Gespach, C .

FASEB JOURNAL, 2000, 14 (14) :2329-2338

[4] Activation of downstream signals by the long form of the leptin receptor [J].

Banks, AS ;

Davis, SM ;

Bates, SH ;

Myers, MG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (19) :14563-14572

[5] Subcellular localization and internalization of the four human leptin receptor isoforms [J].

Barr, VA ;

Lane, K ;

Taylor, SI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (30) :21416-21424

[6] The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors [J].

Baumann, H ;

Morella, KK ;

White, DW ;

Dembski, M ;

Bailon, PS ;

Kim, HK ;

Lai, CF ;

Tartaglia, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8374-8378

[7] Leptin activates Stat3, Stat1 and AP-1 in mouse adipose tissue [J].

Bendinelli, P ;

Maroni, P ;

Giraldi, FP ;

Piccoletti, R .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2000, 168 (1-2) :11-20

[8] Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2 [J].

Berti, L ;

Gammeltoft, S .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1999, 157 (1-2) :121-130

[9] Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a PI3-kinase mediated effect [J].

Berti, L ;

Kellerer, M ;

Capp, E ;

Haring, HU .

DIABETOLOGIA, 1997, 40 (05) :606-609

[10] Divergent signaling capacities of the long and short isoforms of the leptin receptor [J].

Bjorbaek, C ;

Uotani, S ;

da Silva, B ;

Flier, JS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (51) :32686-32695

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