Conditioned place preference to morphine in cannabinoid CB1 receptor knockout mice

被引：43

作者：

Rice, OV ^{[1
]}

Gordon, N ^{[1
]}

Gifford, AN ^{[1
]}

机构：

[1] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

来源：

BRAIN RESEARCH | 2002年 / 945卷 / 01期

关键词：

cannabinoid receptor; morphine; conditioned place preference; opioid reward; CB1; receptor;

D O I：

10.1016/S0006-8993(02)02890-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent reports have suggested an involvement of the brain cannabinoid system in the morphine-reward pathway. To address this question we evaluated whether CB I receptor knockout mice would show a conditioned place preference to morphine. CB I receptor knockout mice developed a strong place preference to 4 and 8 mg/kg morphine, similar to that in wild-type Swiss-Webster mice. This data thus does not support a contribution of the brain cannabinoid system to morphine reward. (C) 2002 Elsevier Science BY All rights reserved.

引用

收藏

页码：135 / 138

页数：4

相关论文

共 7 条

[1] Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse [J].

Cossu, G ;

Ledent, C ;

Fattore, L ;

Imperato, A ;

Böhme, GA ;

Parmentier, M ;

Fratta, W .

BEHAVIOURAL BRAIN RESEARCH, 2001, 118 (01) :61-65

[2] Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice [J].

Ledent, C ;

Valverde, O ;

Cossu, C ;

Petitet, F ;

Aubert, LF ;

Beslot, F ;

Böhme, GA ;

Imperato, A ;

Pedrazzini, T ;

Roques, BP ;

Vassart, G ;

Fratta, W ;

Parmentier, M .

SCIENCE, 1999, 283 (5400) :401-404

[3]

Lichtman AH, 2001, J PHARMACOL EXP THER, V298, P1007

[4] Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice [J].

Martin, M ;

Ledent, C ;

Parmentier, M ;

Maldonado, R ;

Valverde, O .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (11) :4038-4046

[5] Reduction of opioid dependence by the CB1 antagonist SR141716A in mice:: evaluation of the interest in pharmacotherapy of opioid addiction [J].

Mas-Nieto, M ;

Pommier, B ;

Tzavara, ET ;

Caneparo, A ;

Da Nascimento, S ;

Le Fur, G ;

Rogues, BP ;

Noble, F .

BRITISH JOURNAL OF PHARMACOLOGY, 2001, 132 (08) :1809-1816

[6] Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene [J].

Matthes, HWD ;

Maldonado, R ;

Simonin, F ;

Valverde, O ;

Slowe, S ;

Kitchen, I ;

Befort, K ;

Dierich, A ;

LeMeur, M ;

Dolle, P ;

Tzavara, E ;

Hanoune, J ;

Roques, BP ;

Kieffer, BL .

NATURE, 1996, 383 (6603) :819-823

[7] Measuring reward with the conditioned place preference paradigm: A comprehensive review of drug effects, recent progress and new issues [J].

Tzschentke, TM .

PROGRESS IN NEUROBIOLOGY, 1998, 56 (06) :613-672