Electrochemical behaviour of droxicam:: kinetic study in aqueous-organic media

被引：6

作者：

Acuña, JA

de la Fuente, C

Vázquez, MD

Tascón, ML

Gómez, MI

Mata, F

Sánchez-Batanero, P

机构：

[1] Univ Valladolid, Fac Sci, Dept Analyt Chem, E-47005 Valladolid, Spain

[2] Univ Valladolid, Fac Sci, Dept Chem Phys, E-47005 Valladolid, Spain

[3] Univ Nacl Educ Distancia, Fac Sci, Dept Analyt Chem, Madrid 28080, Spain

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 29卷 / 04期

关键词：

droxicam; kinetic study; organic-aqueous media;

D O I：

10.1016/S0731-7085(02)00041-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A kinetic study of the hydrolytic decomposition of droxicam was carried out in order to establish the possible pharmacological action of the drug in the organism of the human being. The electrochemical technique used was scan cyclic voltammetry on a HMDE, giving a well-defined peak. Due to the insolubility of droxicam in water, the working media was a methanol-H2O (4:96, V/V) mixture. The decomposition product of droxicam is piroxicam, which is also reduced on a mercury electrode giving a well-defined cyclic voltammetric peak. It is proposed that the decomposition of droxicam is controlled by a kinetic equation: v = (1.93.10(-3) + 78.9 [D]) [D] = k(D)[D]. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：617 / 624

页数：8

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