Human cytomegalovirus (HCMV) smallest capsid protein identified as product of short open reading frame located between HCMV UL48 and UL49

被引：32

作者：

Gibson, W ^{[1
]}

Clopper, KS ^{[1
]}

Britt, WJ ^{[1
]}

Baxter, MK ^{[1
]}

机构：

[1] UNIV ALABAMA, DEPT PEDIAT, BIRMINGHAM, AL 35233 USA

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 08期

关键词：

D O I：

10.1128/JVI.70.8.5680-5683.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The capsid of cytomegalovirus contains an abundant, lo,v-molecular-weight protein whose coding sequence within the viral genome had not been identified. We have used a combination of biochemical and immunological techniques to demonstrate that this protein, called the smallest capsid protein in human cytomegalovirus, is encoded by a previously unidentified 225-bp open reading frame (ORF) located between ORFs UL48 and UL49. This short ORF, called UL48/49, is the positional homolog of herpes simplex virus ORF UL35 (encoding capsid protein VP26) and shows partial amino acid sequence identity to positional homologs in human herpes viruses 6 and 7.

引用

页码：5680 / 5683

页数：4

共 29 条

[1]

Ausubel F., 1990, CURRENT PROTOCOLS MO

[2] VISCOSITY-DENSITY GRADIENT FOR PURIFICATION OF FOOT-AND-MOUTH DISEASE VIRUS [J].