Association of plasma viral RNA load with prognosis in cats naturally infected with feline immunodeficiency virus

被引：21

作者：

Goto, Y ^{[1
]}

Nishimura, Y ^{[1
]}

Baba, K ^{[1
]}

Mizuno, T ^{[1
]}

Endo, Y ^{[1
]}

Masuda, K ^{[1
]}

Ohno, K ^{[1
]}

Tsujimoto, H ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Internal Med, Bunkyo Ku, Tokyo 1138657, Japan

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 19期

关键词：

D O I：

10.1128/JVI.76.19.10079-10083.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We measured the quantity of plasma feline immunodeficiency virus (FIV) RNA using a real-time sequence detecting system. Plasma viral RNA load was shown to correlate with the clinical stage, survival time, and disease progression in naturally FIV-infected cats. The present study indicates that the plasma viral RNA load can be used as a clinical marker representing the impairment of the immune system and predicting the clinical outcome in FIV-infected cats.

引用

页码：10079 / 10083

页数：5

共 24 条

[1] FELINE IMMUNODEFICIENCY VIRUS - AN INTERESTING MODEL FOR AIDS STUDIES AND AN IMPORTANT CAT PATHOGEN [J].

BENDINELLI, M ;

PISTELLO, M ;

LOMBARDI, S ;

POLI, A ;

GARZELLI, C ;

MATTEUCCI, D ;

CECCHERININELLI, L ;

MALVALDI, G ;

TOZZINI, F .

CLINICAL MICROBIOLOGY REVIEWS, 1995, 8 (01) :87-112

[2] Plasma viral RNA load predicts disease progression in accelerated feline immunodeficiency virus infection [J].

Diehl, LJ ;

MathiasonDubard, CK ;

ONeil, LL ;

Hoover, EA .

JOURNAL OF VIROLOGY, 1996, 70 (04) :2503-2507

[3] LONGITUDINAL ASSESSMENT OF FELINE IMMUNODEFICIENCY VIRUS KINETICS IN PLASMA BY USE OF A QUANTITATIVE COMPETITIVE REVERSE-TRANSCRIPTASE PCR [J].

DIEHL, LJ ;

MATHIASONDUBARD, CK ;

ONELL, LL ;

HOOVER, EA .

JOURNAL OF VIROLOGY, 1995, 69 (04) :2328-2332

[4] Quantification of viral ribonucleic acid in plasma of cats naturally infected with feline immunodeficiency virus [J].

Goto, Y ;

Nishimura, Y ;

Mizuno, T ;

Endo, Y ;

Baba, K ;

Momoi, Y ;

Watari, T ;

Hasegawa, A ;

Tsujimoto, H .

AMERICAN JOURNAL OF VETERINARY RESEARCH, 2000, 61 (12) :1609-1613

[5] RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION [J].

HO, DD ;

NEUMANN, AU ;

PERELSON, AS ;

CHEN, W ;

LEONARD, JM ;

MARKOWITZ, M .

NATURE, 1995, 373 (6510) :123-126

[6]

ISHIDA T, 1990, JPN J VET SCI, V52, P645

[7] PATHOLOGICAL FEATURES OF ACQUIRED IMMUNODEFICIENCY-LIKE SYNDROME IN CATS EXPERIMENTALLY INFECTED WITH FELINE IMMUNODEFICIENCY VIRUS [J].

MATSUMURA, S ;

ISHIDA, T ;

WASHIZU, T ;

TOMODA, I ;

NAGATA, S ;

CHIBA, J ;

KURATA, T .

JOURNAL OF VETERINARY MEDICAL SCIENCE, 1993, 55 (03) :387-394

[8] Prognosis in HIV-1 infection predicted by the quantity of virus in plasma [J].

Mellors, JW ;

Rinaldo, CR ;

Gupta, P ;

White, RM ;

Todd, JA ;

Kingsley, LA .

SCIENCE, 1996, 272 (5265) :1167-1170

[9] Genetic heterogeneity of env gene of feline immunodeficiency virus obtained from multiple districts in Japan [J].

Nishimura, Y ;

Goto, Y ;

Pang, H ;

Endo, Y ;

Mizuno, T ;

Momoi, Y ;

Watari, T ;

Tsujimoto, H ;

Hasegawa, A .

VIRUS RESEARCH, 1998, 57 (01) :101-112

[10] Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS [J].

OBrien, WA ;

Hartigan, PM ;

Martin, D ;

Esinhart, J ;

Hill, A ;

Benoit, S ;

Rubin, M ;

Lahart, C ;

Wray, N ;

Finegold, SM ;

George, WL ;

Dickinson, GM ;

Klimas, N ;

Diamond, G ;

ZollaPazner, SB ;

Jensen, PC ;

Hawkes, C ;

Oster, C ;

Gordin, F ;

Labriola, AM ;

Spivey, P ;

Matthews, T ;

Weinhold, K ;

Drusano, G ;

Egorin, MJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (07) :426-431

← 1 2 3 →