The consensus coding sequences of human breast and colorectal cancers

被引：2744

作者：

Sjoeblom, Tobias

Jones, Sian

Wood, Laura D.

Parsons, D. Williams

Lin, Jimmy

Barber, Thomas D.

Mandelker, Diana

Leary, Rebecca J.

Ptak, Janine

Silliman, Natalie

Szabo, Steve

Buckhaults, Phillip

Farrell, Christopher

Meeh, Paul

Markowitz, Sanford D.

Willis, Joseph

Dawson, Dawn

Willson, James K. V.

Gazdar, Adi F.

Hartigan, James

Wu, Leo

Liu, Changsheng

Parmigiani, Giovanni

Park, Ben Ho

Bachman, Kurtis E.

Papadopoulos, Nickolas

Vogelstein, Bert ^{[1
]}

Kinzler, Kenneth W.

Velculescu, Victor E.

机构：

[1] Johns Hopkins, Ludwig Ctr, Baltimore, MD 21231 USA

[2] Johns Hopkins, Howard Hughes Med Inst, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

[3] Univ S Carolina, Sch Med, S Carolina Canc Ctr, Div Basic Res, Columbia, SC 29229 USA

[4] Univ S Carolina, Sch Med, Ctr Colon Canc Res, Dept Pathol & Microbiol, Columbia, SC 29229 USA

[5] Case Western Reserve Univ, Ireland Canc Ctr, Dept Med, Cleveland, OH 44106 USA

[6] Case Western Reserve Univ, Howard Hughes Med Inst, Cleveland, OH 44106 USA

[7] Univ Hosp Cleveland, Cleveland, OH 44106 USA

[8] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[9] Univ Texas, SW Med Ctr, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA

[10] Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75390 USA

[11] Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol & Res, Dallas, TX 75390 USA

[12] Agencourt Biosci Corp, Beverly, MA 01915 USA

[13] SoftGenet LLC, State Coll, PA 16803 USA

[14] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA

[15] Johns Hopkins Med Inst, Dept Biostat, Baltimore, MD 21205 USA

[16] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

[17] Univ Maryland, Sch Med, Dept Radiat Oncol, Baltimore, MD 21201 USA

[18] Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA

来源：

SCIENCE | 2006年 / 314卷 / 5797期

关键词：

D O I：

10.1126/science.1133427

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two common tumor types. Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of similar to 90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes ( average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention, and open fertile avenues for basic research in tumor biology.

引用

页码：268 / 274

页数：7

共 47 条

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[Anonymous], CANC GENOME ATLAS

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The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10 [J].