Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver

被引：73

作者：

Elli, L. ^{[1
]}

Bergamini, C. M. ^{[2
]}

Bardella, M. T. ^{[1
,3
]}

Schuppan, D. ^{[4
,5
]}

机构：

[1] Fdn IRCCS Osped Maggiore Policlin, Ctr Prevent & Diag Celiac Dis, Milan, Italy

[2] Univ Ferrara, Dept Biochem, I-44100 Ferrara, Italy

[3] Univ Milan, Dept Med Sci, Milan, Italy

[4] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[5] Harvard Univ, Sch Med, Boston, MA USA

来源：

DIGESTIVE AND LIVER DISEASE | 2009年 / 41卷 / 08期

关键词：

Celiac disease; Collagen; Crohn's disease; Extracellular matrix; Gliadin; Inflammatory bowel disease; NFkB; Ulcerative colitis; CROSS-LINKING ENZYMES; HUMAN TISSUE TRANSGLUTAMINASE; GTP-BINDING PROTEIN; CELIAC-DISEASE; RETINOIC ACID; BOWEL-DISEASE; FACTOR-XIII; ANTITISSUE TRANSGLUTAMINASE; SERUM TRANSGLUTAMINASE; SELECTIVE INHIBITORS;

D O I：

10.1016/j.dld.2008.12.095

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Transglutaminases are a family of eight currently known calcium-dependent enzymes that catalyze the cross-linking or deamidation of proteins. They are involved in important biological processes such as wound healing, tissue repair, fibrogenesis, apoptosis, inflammation and cell-cycle control. Therefore, they play important roles in the pathomechanisms of autoimmune, inflammatory and degenerative diseases, many of which affect the gastrointestinal system. Transglutaminase 2 is prominent, since it is central to the pathogenesis of celiac disease, and modulates inflammation and fibrosis in inflammatory bowel and chronic liver diseases. This review highlights our present understanding of transglutaminase function in gastrointestinal and liver diseases and therapeutic strategies that target transglutaminase activities. (c) 2008 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：541 / 550

页数：10

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