Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way

被引：173

作者：

Carmeliet, Peter ^{[1
]}

De Smet, Frederik ^{[1
]}

Loges, Sonja ^{[1
]}

Mazzone, Massimiliano ^{[1
]}

机构：

[1] Katholieke Univ Leuven VIB, Vesalius Res Ctr, B-3000 Louvain, Belgium

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2009年 / 6卷 / 06期

关键词：

ENDOTHELIAL-GROWTH-FACTOR; REGULATES TUMOR ANGIOGENESIS; NOTCH LIGAND JAGGED1; VESSEL MATURATION; PATHOLOGICAL ANGIOGENESIS; VASCULAR NORMALIZATION; EMBRYONIC LETHALITY; NETWORK FORMATION; BLOOD-VESSELS; MOUSE EMBRYOS;

D O I：

10.1038/nrclinonc.2009.64

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

From the original concepts that tumors require a vascular supply to grow and that blocking angiogenesis could suppress tumor growth, the oncology field has witnessed clinical successes of VEGF-targeted antiangiogenic medicine. The field is now facing the challenge of overcoming resistance to VEGF-targeted therapy, and therefore additional angiogenesis inhibitors are being developed. studies on how endothelial 'tip, stalk and phalanx cells' form sprouts have identified promising candidate targets with complementary mechanisms to VEGF. This review provides a conceptual framework in which molecular discoveries and principles are discussed in light of clinical opportunities to develop new antiangiogenic agents.

引用

页码：315 / 326

页数：12

共 89 条

[1]

Tracheal branching morphogenesis in Drosophila:: new insights into cell behaviour and organ architecture [J].

Affolter, Markus ;

Caussinus, Emmanuel .

DEVELOPMENT, 2008, 135 (12) :2055-2064

[2]

Role of PIGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 [J].

Autiero, M ;

Waltenberger, J ;

Communi, D ;

Kranz, A ;

Moons, L ;

Lambrechts, D ;

Kroll, J ;

Plaisance, S ;

De Mol, M ;

Bono, F ;

Kliche, S ;

Fellbrich, G ;

Ballmer-Hofer, K ;

Maglione, D ;

Mayr-Beyrle, U ;

Dewerchin, M ;

Dombrowski, S ;

Stanimirovic, D ;

Van Hummelen, P ;

Dehio, C ;

Hicklin, DJ ;

Persico, G ;

Herbert, JM ;

Communi, D ;

Shibuya, M ;

Collen, D ;

Conway, EM ;

Carmeliet, P .

NATURE MEDICINE, 2003, 9 (07) :936-943

[3]

Cellular abnormalities of blood vessels as targets in cancer [J].

Baluk, P ;

Hashizume, H ;

McDonald, DM .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2005, 15 (01) :102-111

[4]

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients [J].

Batchelor, Tracy T. ;

Sorensen, A. Gregory ;

di Tomaso, Emmanuelle ;

Zhang, Wei-Ting ;

Duda, Dan G. ;

Cohen, Kenneth S. ;

Kozak, Kevin R. ;

Cahill, Daniel P. ;

Chen, Poe-Jou ;

Zhu, Mingwang ;

Ancukiewicz, Marek ;

Mrugala, Maciej M. ;

Plotkin, Scott ;

Drappatz, Jan ;

Louis, David N. ;

Ivy, Percy ;

Scadden, David T. ;

Benner, Thomas ;

Loeffler, Jay S. ;

Wen, Patrick Y. ;

Jain, Rakesh K. .

CANCER CELL, 2007, 11 (01) :83-95

[5]

Neuropilins in neoplasms: Expression, regulation, and function [J].

Bielenberg, DR ;

Pettaway, CA ;

Takashima, S ;

Klagsbrun, M .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (05) :584-593

[6]

γ-secretase:: a multifaceted regulator of angiogenesis [J].

Boulton, Michael E. ;

Cai, Jun ;

Grant, Maria B. .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2008, 12 (03) :781-795

[7]

Role of HIF-1α or in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis [J].

Carmeliet, P ;

Dor, Y ;

Herbert, JM ;

Fukumura, D ;

Brusselmans, K ;

Dewerchin, M ;

Neeman, M ;

Bono, F ;

Abramovitch, R ;

Maxwell, P ;

Koch, CJ ;

Ratcliffe, P ;

Moons, L ;

Jain, RK ;

Collen, D ;

Keshet, E .

NATURE, 1998, 394 (6692) :485-490

[8]

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions [J].

Carmeliet, P ;

Moons, L ;

Luttun, A ;

Vincenti, V ;

Compernolle, V ;

De Mol, M ;

Wu, Y ;

Bon, F ;

Devy, L ;

Beck, H ;

Scholz, D ;

Acker, T ;

DiPalma, T ;

Dewerchin, M ;

Noel, A ;

Stalmans, I ;

Barra, A ;

Blacher, S ;

Vandendriessche, T ;

Ponten, A ;

Eriksson, U ;

Plate, KH ;

Foidart, JM ;

Schaper, W ;

Charnock-Jones, DS ;

Hicklin, DJ ;

Herbert, JM ;

Collen, D ;

Persico, MG .

NATURE MEDICINE, 2001, 7 (05) :575-583

[9]

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele [J].

Carmeliet, P ;

Ferreira, V ;

Breier, G ;

Pollefeyt, S ;

Kieckens, L ;

Gertsenstein, M ;

Fahrig, M ;

Vandenhoeck, A ;

Harpal, K ;

Eberhardt, C ;

Declercq, C ;

Pawling, J ;

Moons, L ;

Collen, D ;

Risau, W ;

Nagy, A .

NATURE, 1996, 380 (6573) :435-439

[10]

Blocking neuropilin-2 function inhibits tumor cell metastasis [J].

Caunt, Maresa ;

Mak, Judy ;

Liang, Wei-Ching ;

Stawicki, Scott ;

Pan, Qi ;

Tong, Raymond K. ;

Kowalski, Joe ;

Ho, Calvin ;

Reslan, Hani Bou ;

Ross, Jed ;

Berry, Leanne ;

Kasman, Ian ;

Zlot, Constance ;

Cheng, Zhiyong ;

Le Couter, Jennifer ;

Filvaroff, Ellen H. ;

Plowman, Greg ;

Peale, Franklin ;

French, Dorothy ;

Carano, Richard ;

Koch, Alexander W. ;

Wu, Yan ;

Watts, Ryan J. ;

Tessier-Lavigne, Marc ;

Bagri, Anil .

CANCER CELL, 2008, 13 (04) :331-342

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