Bacterial adhesion and entry into host cells

被引:725
作者
Pizarro-Cerdá, J
Cossart, P
机构
[1] Inst Pasteur, Unite Interact Bacteries Cellules, F-75015 Paris, France
[2] INSERM, U604, F-75015 Paris, France
[3] INRA, F-75015 Paris, France
关键词
D O I
10.1016/j.cell.2006.02.012
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Successful establishment of infection by bacterial pathogens requires adhesion to host cells, colonization of tissues, and in certain cases, cellular invasion-followed by intracellular multiplication, dissemination to other tissues, or persistence. Bacteria use monomeric adhesins/invasins or highly sophisticated macromolecular machines such as type III secretion systems and retractile type IV pili to establish a complex host/pathogen molecular crosstalk that leads to subversion of cellular functions and establishment of disease.
引用
收藏
页码:715 / 727
页数:13
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