Oriented loading of FtsK on KOPS

被引：76

作者：

Bigot, Sarah

Saleh, Omar A.

Cornet, Francois

Allemand, Jean-Francois

Barre, Francois-Xavier ^{[1
]}

机构：

[1] CNRS, Ctr Genet Mol, UPR 2167, Gif Sur Yvette, France

[2] CNRS, Lab Microbiol & Genet Mol, UMR 5100, Toulouse, France

[3] Univ Paris 06, Lab Phys Stat, Paris, France

[4] Univ Paris 07, Lab Phys Stat, Paris, France

[5] Univ Paris 06, Dept Biol, Ecole Normale Super, CNRS,UMR 8550, Paris, France

[6] Univ Paris 07, Dept Biol, Ecole Normale Super, CNRS,UMR 8550, Paris, France

[7] Ecole Normale Super, Lab Pasteur, Dept Chim, F-75231 Paris, France

[8] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA

[9] Univ Calif Santa Barbara, Biomol Sci & Engn Program, Santa Barbara, CA 93106 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 11期

关键词：

D O I：

10.1038/nsmb1159

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Escherichia coli, the ATP-dependent DNA translocase FtsK transports DNA across the site of cell division and activates recombination by the XerCD recombinases at a specific site on the chromosome, dif, to ensure the last stages of chromosome segregation. DNA transport by FtsK is oriented by 8-base-pair asymmetric sequences ('KOPS'). Here we provide evidence that KOPS promote FtsK loading on DNA and that translocation is oriented at this step.

引用

页码：1026 / 1028

页数：3

共 5 条

[1] KOPS:: DNA motifs that control E-coli chromosome segregation by orienting the FtsK translocase [J].