Finite mixture models for proportions

被引:39
作者
Brooks, SP
Morgan, BJT
Ridout, MS
Pack, SE
机构
[1] UNIV KENT,INST MATH & STAT,CANTERBURY CT2 7NF,KENT,ENGLAND
[2] HORT RES INT,MAIDSTONE ME19 6BJ,KENT,ENGLAND
[3] PROCTER & GAMBLE CO,PHARMACEUT,EUROPEAN RES & DEV,STAINES TW18 3AZ,MIDDX,ENGLAND
关键词
beta-binomial; beta-correlated-binomial; CAMAN; correlated-binomial; fetal death; information criteria; mixture models; Monte Carlo tests; multiple maxima; nonparametric maximum likelihood; overdispersion; profile log-likelihoods; simulated annealing; Wolfe's criterion;
D O I
10.2307/2533567
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Six data sets recording fetal control mortality in mouse litters are presented. The data are clearly overdispersed, and a standard approach would be to describe the data by means of a beta-binomial model or to use quasi-likelihood methods. For five of the examples, we show that the beta-binomial model provides a reasonable description but that the fit can be significantly improved by using a mixture of a beta-binomial model with a binomial distribution. This mixture provides two alternative solutions, in one of which the binomial component indicates a high probability of death but is selected infrequently; this accounts for outlying litters with high mortality. The influence of the outliers on the beta-binomial fits is also demonstrated. The location and nature of the two main maxima to the likelihood are investigated through profile log-likelihoods. Comparisons are made with the performance of finite mixtures of binomial distributions.
引用
收藏
页码:1097 / 1115
页数:19
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