Use of Azathioprine and 6MP in Postoperative Crohn's: Changing Natural History or Just Along for the Ride?

被引：4

作者：

Velayos, Fernando S. ^{[1
]}

Sandborn, William J. ^{[2
]}

机构：

[1] Univ Calif San Francisco, Div Gastroenterol & Hepatol, Ctr Crohns & Colitis, San Francisco, CA 94115 USA

[2] Mayo Clin & Mayo Fdn, Inflammatory Bowel Dis Clin, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2009年 / 104卷 / 08期

关键词：

DOUBLE-BLIND; DISEASE RECURRENCE; PREVENTION; MESALAMINE; PLACEBO; PROPHYLAXIS; RESECTION; RELAPSE; TRIAL; 6-MERCAPTOPURINE;

D O I：

10.1038/ajg.2009.306

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There is currently no standard of care for the management of postoperative Crohn's disease (CD), partly because data from definitive trials are lacking. Despite the absence of such data, many experts advocate the selective use of azathioprine (AZA) or 6-mercaptopurine (6MP) in the prevention of postoperative recurrence in patients with risk factors for recurrence. In the current issue of The American Journal of Gastroenterology, Peyrin-Biroulet and colleagues quantified the efficacy of AZA/6MP in this setting by performing a meta-analysis of AZA/6MP trials. The implications of this work, both for the current management of postoperative Crohn's and the future design of clinical trials that are definitive in this group of patients, are discussed.

引用

页码：2097 / 2099

页数：3

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