Challenges for Biomarker Discovery in Body Fluids Using SELDI-TOF-MS

被引：68

作者：

De Bock, Muriel ^{[1
]}

de Seny, Dominique ^{[2
]}

Meuwis, Marie-Alice

Chapelle, Jean-Paul ^{[1
]}

Louis, Edouard ^{[3
]}

Malaise, Michel ^{[2
]}

Merville, Marie-Paule ^{[1
]}

Fillet, Marianne ^{[1
]}

机构：

[1] Univ Liege, CHU, Clin Chem Lab, GIGA Res, B-4000 Liege 1, Belgium

[2] Univ Liege, CHU, Dept Rheumatol, GIGA Res, B-4000 Liege 1, Belgium

[3] Univ Liege, CHU, Dept Hepatogastroenterol, GIGA Res, B-4000 Liege 1, Belgium

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2010年

关键词：

FLIGHT MASS-SPECTROMETRY; LASER-DESORPTION/IONIZATION-TIME; SERUM-PROTEIN PROFILES; NIPPLE ASPIRATE FLUID; CLINICAL PROTEOMICS; PROSTATE-CANCER; BREAST-CANCER; PLASMA-PROTEOME; CEREBROSPINAL-FLUID; SAMPLE COLLECTION;

D O I：

10.1155/2010/906082

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Protein profiling using SELDI-TOF-MS has gained over the past few years an increasing interest in the field of biomarker discovery. The technology presents great potential if some parameters, such as sample handling, SELDI settings, and data analysis, are strictly controlled. Practical considerations to set up a robust and sensitive strategy for biomarker discovery are presented. This paper also reviews biological fluids generally available including a description of their peculiar properties and the preanalytical challenges inherent to sample collection and storage. Finally, some new insights for biomarker identification and validation challenges are provided.

引用

页数：15

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