Autophagy takes flight in Drosophila

被引：106

作者：

Chang, Yu-Yun ^{[1
]}

Neufeld, Thomas P. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 07期

关键词：

Autophagy-related gene 1; Unc-51 like kinase 1; Vps34; Jun-N-terminal kinase; Target of rapamycin; STARVATION-INDUCED AUTOPHAGY; CELL-DEATH; FAT-BODY; LIFE-SPAN; NEURODEGENERATIVE DISEASE; SACCHAROMYCES-CEREVISIAE; PROGRAMMED AUTOPHAGY; STEROID REGULATION; KINASE COMPLEX; C-ELEGANS;

D O I：

10.1016/j.febslet.2010.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Drosophila has been shown to be a powerful model to study autophagy, whose regulation involves a core machinery consisting of Atg proteins and upstream signaling regulators similar to those in yeast and mammals. The conserved role in degrading proteins and organelles gives autophagy an important function in coordinating several cellular processes as well as in a number of pathological conditions. This review summarizes key studies in Drosophila autophagy research and discusses potential questions that may lead to better understanding of the roles and regulation of autophagy in higher eukaryotes. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1342 / 1349

页数：8

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