CD4 memory T cells: What are they and what can they do?

被引：113

作者：

MacLeod, Megan K. L. ^{[1
,2
]}

Clambey, Eric T. ^{[1
,2
]}

Kappler, John W. ^{[1
,2
,3
,4
]}

Marrack, Philippa ^{[1
,2
,4
,5
]}

机构：

[1] Natl Jewish Hlth, Howard Hughes Med Inst, Denver, CO USA

[2] Natl Jewish Hlth, Integrated Dept Immunol, Denver, CO USA

[3] Univ Colorado Denver, Sch Med, Program Biomol Struct, Aurora, CO 80045 USA

[4] Univ Colorado Denver, Sch Med, Dept Med, Aurora, CO 80045 USA

[5] Univ Colorado Denver, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA

来源：

SEMINARS IN IMMUNOLOGY | 2009年 / 21卷 / 02期

关键词：

CD4; Cytokine; Help; Memory; Protection; MYCOBACTERIUM-TUBERCULOSIS INFECTION; CLASS-II TETRAMERS; IMMUNOLOGICAL MEMORY; CUTTING EDGE; PROTECTIVE IMMUNITY; IN-VIVO; VIRAL-INFECTION; EX-VIVO; B-CELLS; INTERFERON-GAMMA;

D O I：

10.1016/j.smim.2009.02.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Immunological memory provides the basis for Successful vaccines. It is important to understand the properties of memory cells. There is much known about the phenotype and functions of memory CD8 T cells, less about memory B cells, while CD4 memory T cells have proved difficult to study. Differences in the types of memory CD4 cells studied and the difficulties of tracking the small number of cells have led to conflicting and unclear results. Here we discuss the different systems used to study CD4 memory cells and ask whether, and in what circumstances, memory CD4 cells Could provide protection against infections. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：53 / 61

页数：9

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