Zinc in the physiology and pathology of the CNS

被引：589

作者：

Sensi, Stefano L. ^{[1
,2
,3
]}

Paoletti, Pierre ^{[4
]}

Bush, Ashley I. ^{[5
,6
]}

Sekler, Israel ^{[7
]}

机构：

[1] Univ G DAnnunzio, Dept Basic & Appl Med Sci, I-66013 Chieti, Italy

[2] Univ G DAnnunzio, Mol Neurol Unit, CeSI Ctr Excellence Aging, I-66013 Chieti, Italy

[3] Univ Calif Irvine, Dept Neurol, Irvine, CA 92697 USA

[4] Ecole Normale Super, CNRS, Neurobiol Lab, F-75005 Paris, France

[5] Mental Hlth Res Inst, Parkville, Vic 3052, Australia

[6] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia

[7] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Physiol, Beer Sheva, Israel

来源：

NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 11期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

SYNAPTICALLY-RELEASED ZINC; TRANSIENT FOREBRAIN ISCHEMIA; AMYLOID-BETA OLIGOMERS; TARGETING A-BETA; ALZHEIMERS-DISEASE; INTRACELLULAR ZINC; CELL-DEATH; CORTICAL-NEURONS; NITRIC-OXIDE; ZNT-1; EXPRESSION;

D O I：

10.1038/nrn2734

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology. The recent development of powerful tools, including zinc-sensitive fluorescent probes, selective chelators and genetically modified animal models, has brought a deeper understanding of the roles of this cation as a crucial intra- and intercellular signalling ion of the CNS, and hence of the neurophysiological importance of zinc-dependent pathways and the injurious effects of zinc dyshomeostasis. The development of some innovative therapeutic strategies is aimed at controlling and preventing the damaging effects of this cation in neurological conditions such as stroke and Alzheimer's disease.

引用

页码：780 / U38

页数：13

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