Prophylaxis of heterotopic ossification after total hip arthroplasty -: A prospective randomized study comparing indomethacin and meloxicam

被引：26

作者：

Barthel, T ^{[1
]}

Baumann, B ^{[1
]}

Nöth, U ^{[1
]}

Eulert, J ^{[1
]}

机构：

[1] Univ Wurzburg, Dept Orthopaed Surg, DE-97074 Wurzburg, Germany

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 2002年 / 73卷 / 06期

关键词：

D O I：

10.1080/000164702321039543

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

We performed a randomized, prospective study on the prophylaxis of heterotopic ossification (HO) after total hip arthroplasty (THR), comparing indomethacin and the selective COX-2 inhibitor meloxicam. From the day after surgery, 272 patients were treated with 7.5 mg meloxicam, 15 mg meloxicam, or 2 x 50 mg indomethacin a day, for 14 days. After 6 months, radiographs of patients treated with 7.5 mg meloxicam showed that HO had occurred in one third. This treatment was therefore stopped after 26 patients have been assigned to this group. According to the intention-to-treat principle, patients given 15 mg meloxicam developed HO in 25% (20% Brooker grade I, 4% grade II and 1% grade III) and those given indomethacin in 10% (7% Brooker grade I, 1% grade II and 2% grade III), a statistically significant difference.

引用

页码：611 / 614

页数：4

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