Dual oxidases and hydrogen peroxide in a complex dialogue between host mucosae and bacteria

被引：42

作者：

Allaoui, Abdelmounaaim ^{[2
]}

Botteaux, Anne ^{[2
]}

Dumont, Jacques E. ^{[1
]}

Hoste, Candice ^{[1
]}

De Deken, Xavier ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Inst Interdisciplinary Res IRIBHM, B-1070 Brussels, Belgium

[2] Univ Libre Bruxelles, Lab Bacteriol Mol, B-1070 Brussels, Belgium

来源：

TRENDS IN MOLECULAR MEDICINE | 2009年 / 15卷 / 12期

关键词：

AIRWAY EPITHELIAL-CELLS; DROSOPHILA GUT IMMUNITY; MUC5AC MUCIN EXPRESSION; NADPH OXIDASE; CONGENITAL HYPOTHYROIDISM; REACTIVE OXYGEN; CYSTIC-FIBROSIS; NOX ENZYMES; SALMONELLA-TYPHIMURIUM; SIGNALING PATHWAYS;

D O I：

10.1016/j.molmed.2009.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Among the host defense mechanisms against bacteria, leukocyte phagocytosis leads to their hydrogen peroxide (H2O2)-mediated destruction. The recent discovery of dual oxidase (DUOX)-dependent H2O2 generation associated with peroxidase and thiocyanate secretion at the apex of mucosal cells has been similarly interpreted as a killing mechanism. However, the rapid degradation of H2O2 would be expected to reduce the efficiency of this system. It has been demonstrated that H2O2 acts as a chemorepellent for bacteria, and such an effect might be sufficient to block cellular infection. Therefore, H2O2 generation might represent one of the mechanisms that allows the coexistence of mucosae with potentially harmful bacteria. Here, we discuss the possible role of DUOXes and H2O2 in interactions between host mucosae and bacteria to maintain mucosal homeostasis.

引用

页码：571 / 579

页数：9

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