Synthesis of sulfo and sialyl Lewis(X) analogs with a mannose at the reducing end

被引：13

作者：

Huang, BG ^{[1
]}

Locke, RD ^{[1
]}

Jain, RK ^{[1
]}

Matta, KL ^{[1
]}

机构：

[1] ROSWELL PK CANC INST,DEPT GYNECOL ONCOL,BUFFALO,NY 14216

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(97)00181-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Stereoselective syntheses of 3-O-sulfo and 3-O-sialyl Lewis(X) analogs 1 and 2 were accomplished. Compound 1 showed greater inhibitory activity than the natural ligand sialyl Lewis(X) against P and L-selectin.

引用

页码：1157 / 1160

页数：4

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