Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis

被引：62

作者：

Konoshima, T ^{[1
]}

Takasaki, M

Ichiishi, E

Murakami, T

Tokuda, H

Nishino, H

Duc, NM

Kasai, R

Yamasaki, K

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078414, Japan

[2] Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6020841, Japan

[3] Ho Chi Minh City Univ Med & Pharm, Ho Chi Minh City, Vietnam

[4] Hiroshima Univ, Sch Med, Inst Pharmaceut Sci, Hiroshima 7348551, Japan

来源：

CANCER LETTERS | 1999年 / 147卷 / 1-2期

关键词：

cancer chemopreventive activity; majonoside-R2; panax vietnamensis; NOR1; peroxinitrite; hepatic tumor inhibitor;

D O I：

10.1016/S0304-3835(99)00257-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Panax plants were screened. Consequently, the ocotillol-type saponin, majonoside-R2 (MR2), was obtained from the rhizome and root of Panax vietnamensis (Vietnamese ginseng) as an active constituent. MR2 exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse hepatic tumor using N-nitrosodiethylamine (DEN) as an initiator and phenobarbital (PB) as a promoter. Further, MR2 exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin induced by nitric oxide (NO) donor/12-O-tetradecanoylphorbol-13-acetate (TPA) or peroxynitrite/TPA. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：11 / 16

页数：6

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