Core promoter mutations (A1762T and G1764A) and viral genotype in chronic hepatitis B and hepatocellular carcinoma in Guangxi, China

被引：44

作者：

Fang, ZL

Yang, JY

Ge, XM

Zhuang, H

Gong, J

Li, RC

Ling, R

Harrison, TJ

机构：

[1] UCL, Royal Free & Univ Coll Med Sch, Ctr Hepatol, London NW3 2PF, England

[2] Ctr Dis Control & Prevent Guangxi, Nanning, Guangxi, Peoples R China

[3] Worker Hosp Guangxi, Nanning, Guangxi, Peoples R China

[4] Beijing Univ, Dept Med, Beijing 100871, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2002年 / 68卷 / 01期

关键词：

genotype; precore mutants; cirrhosis; risk factors;

D O I：

10.1002/jmv.10167

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis B viruses (HBV) with core promoter mutations (A(1762)T, G(1764)A) were found in a previous study to be highly prevalent in patients from Guangxi, China with hepatocellular carcinoma (HCC). The aim of this study was to determine whether the mutations are prevalent in areas of Guangxi with high and lower incidences of HCC and whether they are associated with other severe sequelae of chronic hepatitis B, including the development of cirrhosis. In addition,the genotypes of the various HBV sequences were determined. Core promoter mutations were significantly more common in HCC patients than asymptomatic carriers from both regions of Guangxi and also were common in patients with cirrhosis and chronic hepatitis. The data also support the hypothesis that genotype C HBV causes more severe liver disease than does genotype B. (C) 2002 Wiley-Liss, Inc.

引用

页码：33 / 40

页数：8

共 57 条

[1]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[2] Association of mutations in the core promoter and precore region of hepatitis virus with fulminant and severe acute hepatitis in Japan [J].