Serotonin transporter gene and obese females with impulsivity

被引：10

作者：

Camarena, B

Ruvinskis, E

Santiago, H

Montiel, F

Cruz, C

González-Barranco, J

Nicolini, H ^{[1
]}

机构：

[1] Inst Nacl Psiquiatria Ramon Fuente Muniz, Dept Genet Psiquiatr, Mexico City 14370, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Dept Psicol Med Psiquatria & Salud Mental, Mexico City, DF, Mexico

[3] Inst Nacl Ciencias Med Nutr Salvador Zubiran, Clin Obesidad, Mexico City, DF, Mexico

来源：

MOLECULAR PSYCHIATRY | 2002年 / 7卷 / 08期

关键词：

D O I：

10.1038/sj.mp.4001096

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The authors analyzed the effect of serotonin transporter genetic (5HTT) variants on susceptibility to obesity using a family-based method. Obese females with impulsivity showed a preferential transmission of allele 'l' (X2TDT=4.24, P=0.03). This finding might indicate that gender differences in the function of the serotonin system could be relevant as a risk factor for the development of psychopathological traits such as impulsivity in females with obesity.

引用

页码：829 / 830

页数：2

共 9 条

[1] Obesity: What mental health professionals need to know
Devlin, MJ
Yanovski, SZ
Wilson, GT
[J]. AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (06) : 854 - 866
[2] Association of a functional 5-HT transporter gene polymorphism with anorexia nervosa and food intake
Fumeron, F
Betoulle, D
Aubert, R
Herbeth, B
Siest, G
Rigaud, D
[J]. MOLECULAR PSYCHIATRY, 2001, 6 (01) : 9 - 10
[3] Heils A, 1996, J NEUROCHEM, V66, P2621
[4] Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa
Hinney, A
Barth, N
Ziegler, A
vonPrittwitz, S
Hamann, A
Hennighausen, K
Pirke, KM
Heils, A
Rosenkranz, K
Roth, H
Coners, H
Mayer, H
Herzog, W
Siegfried, A
Lehmkuhl, G
Poustka, F
Schmidt, MH
Schafer, H
Grzeschik, KH
Lesch, KP
Lentes, KU
Remschmidt, H
Hebebrand, J
[J]. LIFE SCIENCES, 1997, 61 (21) : PL295 - PL303
[5] GENETIC DISSECTION OF COMPLEX TRAITS - GUIDELINES FOR INTERPRETING AND REPORTING LINKAGE RESULTS
LANDER, E
KRUGLYAK, L
[J]. NATURE GENETICS, 1995, 11 (03) : 241 - 247
[6] Hypothalamic serotonin in control of eating behavior, meal size, and body weight
Leibowitz, SF
Alexander, JT
[J]. BIOLOGICAL PSYCHIATRY, 1998, 44 (09) : 851 - 864
[7] Serotonin transporter (SERT) mRNA and binding site densities in male rat brain affected by sex steroids
McQueen, JK
Wilson, H
Sumner, BEH
Fink, G
[J]. MOLECULAR BRAIN RESEARCH, 1999, 63 (02): : 241 - 247
[8] Paez F, 1996, SALUD MENT, V19, P10
[9] SPIELMAN RS, 1993, AM J HUM GENET, V42, P337

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