Transforming growth factor beta production during rat cytomegalovirus infection

被引：21

作者：

Haagmans, BL

Teerds, KJ

vandenEijndenvanRaaij, AJM

Horzinek, MC

Schijns, VECJ

机构：

[1] UNIV UTRECHT, FAC VET, DEPT HISTOL & CELL BIOL, NL-3584 CL UTRECHT, NETHERLANDS

[2] UNIV UTRECHT, NETHERLANDS INST DEV BIOL, HUBRECHT LAB, NL-3584 CL UTRECHT, NETHERLANDS

来源：

JOURNAL OF GENERAL VIROLOGY | 1997年 / 78卷

关键词：

D O I：

10.1099/0022-1317-78-1-205

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We analysed the production of transforming growth factor beta (TGF-beta) during a cytomegalovirus (CMV) infection in a rat model system. Splenocytes from immunocompetent rats infected with rat CMV (RCMV) released increased amounts of TGF-beta(1). TGF-beta production was also evident in RCMV-infected radiation-immunosuppressed rats; their sera inhibited the interleukin 2-induced proliferation of T cells, which could be restored by anti-TGF-beta antibodies. In addition, TGF-beta production could be visualized immunohistologically in the lungs, spleen, liver and bone marrow of radiation-immunosuppressed infected rats. The virus directly induced this cytokine since TGF-beta was produced upon RCMV infection in vitro. The induction of TGF-beta production may contribute to immunosuppression during CMV infection.

引用

页码：205 / 213

页数：9

共 45 条

[1] ANTAGONISTIC MODULATION OF HUMAN CYTOMEGALOVIRUS REPLICATION BY TRANSFORMING GROWTH-FACTOR-BETA AND BASIC FIBROBLASTIC GROWTH-FACTOR [J].