Chromosome 6 suffers frequent and multiple aberrations in thymoma

被引：57

作者：

Inoue, M ^{[1
]}

Marx, A ^{[1
]}

Zettl, A ^{[1
]}

Ströbel, P ^{[1
]}

Müller-Hermelink, HK ^{[1
]}

Starostik, P ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Pathol, D-8700 Wurzburg, Germany

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2002年 / 161卷 / 04期

关键词：

D O I：

10.1016/S0002-9440(10)64426-4

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Thymoma is the most frequent tumor arising in human thymus. In this study, we performed a detailed mapping of deleted regions on chromosome 6 shown previously to harbor the most frequent genetic aberrations in this cancer. We analyzed 40 thymomas using 41 microsatellites. Two hundred ninety-four (23.5%) of 1253 informative genotypes showed loss of heterozygosity (LOH), only 39 (2.4%) were positive for microsatellite instability (MSI). Genetic aberrations on chromosome 6 were found in 31 of 40 cases (77.5%) in five hot spots. The most frequent LOHs (48.6%) occurred in region 6q25.2 within a 0.7-Mb interval flanked by markers D6S441 and D6S290. Another hot spot showing LOH in 32.4% of tumors was located between markers D6S442 and D6S1708 (0.4 Mb apart) on 6q25.2-25.3, just 1.1 Mb from the D6S441-D6S290 deletions. The third hot spot (30%) showing LOH appeared in region 6p21.31 including the MHC locus (markers D6S1666-D6S1560, 1 Mb apart). The fourth hot spot (26.3%) was detected on 6q14.1-14-3 (D6S1596-D6S284, 5.2 Mb apart). Some tumors (21.6%) showed LOHs within a fifth hot spot on 6q21 (D6S447-D6S1592, 0.3 Mb apart). Thus, several tumor suppressor genes on chromosome 6 seem to be involved in the pathogenesis of thymoma.

引用

页码：1507 / 1513

页数：7

共 48 条

[1]

[Anonymous], 1999, WHO INT HISTOLOGICAL

[2] A DIFFERENTIAL-AVIDITY MODEL FOR T-CELL SELECTION [J].

ASHTONRICKARDT, PG ;

TONEGAWA, S .

IMMUNOLOGY TODAY, 1994, 15 (08) :362-366

[3] Requirement for diverse, low-abundance peptides in positive selection of T cells [J].

Barton, GM ;

Rudensky, AY .

SCIENCE, 1999, 283 (5398) :67-70

[4]

Bastian BC, 1998, CANCER RES, V58, P2170

[5]

Bell DW, 1997, CANCER RES, V57, P4057

[6]

Bevan S, 2000, BLOOD, V96, P3982

[7]

DRUEY KM, 2001, SCI STKE, V104, pRE14, DOI DOI 10.1126/STKE.2001.1104.RE1114

[8] HLA class I expression and chromosomal deletions at 6p and 15q in head and neck squamous cell carcinomas [J].

Feenstra, M ;

Veltkamp, M ;

van Kuik, J ;

Wiertsema, S ;

Slootweg, P ;

van den Tweel, J ;

de Weger, R ;

Tilanus, M .

TISSUE ANTIGENS, 1999, 54 (03) :235-245

[9] Positive and negative CD4(+) thymocyte selection by a single MHC clas II peptide ligand affected by its expression level in the thymus [J].

Fukui, Y ;

Ishimoto, T ;

Utsuyama, M ;

Gyotoku, T ;

Koga, T ;

Nakao, K ;

Hirokawa, K ;

Katsuki, M ;

Sasazuki, T .

IMMUNITY, 1997, 6 (04) :401-410

[10]

Honchel R, 1996, CANCER RES, V56, P145

← 1 2 3 4 5 →