To ERR in the estrogen pathway

被引：427

作者：

Giguère, V ^{[1
]}

机构：

[1] McGill Univ, Ctr Hlth, Mol Oncol Grp, Montreal, PQ H3A 1A1, Canada

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2002年 / 13卷 / 05期

关键词：

D O I：

10.1016/S1043-2760(02)00592-1

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Estrogens control a variety of physiological and disease-linked processes, most notably reproduction, bone remodeling and breast cancer, and their effects are transduced through classic nuclear receptors referred to as estrogen receptor-alpha (ERalpha) and ERbeta. Recent results obtained using the estrogen-related receptors (ERRalpha, -beta and -gamma), a subfamily of orphan nuclear receptors closely related to the ERs, have shown that the ERRs share target genes, coregulatory proteins, ligands and sites of action with the ERs. In addition, the ERRS can actively influence the estrogenic response, suggesting that pharmacological modulation of ERR activity will be clinically useful to prevent and/or treat a variety of conditions related to women's health.

引用

页码：220 / 225

页数：6

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