Interleukin-12 promotes neurite outgrowth in mouse sympathetic superior cervical ganglion neurons

被引：16

作者：

Lin, HY ^{[1
]}

Hikawa, N ^{[1
]}

Takenaka, T ^{[1
]}

Ishikawa, Y ^{[1
]}

机构：

[1] Yokohama City Univ, Sch Med, Dept Physiol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

来源：

NEUROSCIENCE LETTERS | 2000年 / 278卷 / 03期

关键词：

interleukin-12; sympathetic cervical ganglia; macrophage; neurite outgrowth; nerve regeneration;

D O I：

10.1016/S0304-3940(99)00913-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine the role of cytokines in the nervous system, we examined the effect of interleukin-12(IL-12) on the nerve regeneration of mouse superior cervical ganglion cells (SCG). IL-12 enhanced the neurite outgrowth in a concentration-dependent manner. Immunocytochemical studies demonstrated the expression of IL-12 receptors in neuronal bodies and neurites. The mRNA expression of IL-12 receptors in SCG cells was confirmed by reverse transcription-polymerase chain reaction. Our data demonstrated the presence of IL-12 receptors in sympathetic neurons and suggest that IL-12 plays an important role in neuronal regeneration, (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：129 / 132

页数：4

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