Transcriptional control of epidermal specification and differentiation

被引：79

作者：

Dai, X

Segre, JA

机构：

[1] Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92697 USA

[2] NHGRI, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 05期

关键词：

D O I：

10.1016/j.gde.2004.07.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent experiments reveal the role of transcription factors in integrating upstream signals to execute specification and differentiation of epidermal cells. Based on the skin phenotype observed with misregulation of transcription factors such as p63, c-Myc, RelA, pRb, Klf4 and others, their function in controlling proliferation and differentiation is dissected. Understanding the pathways regulated by these factors and their coordinate interactions remains a challenge for the future.

引用

收藏

页码：485 / 491

页数：7

相关论文

共 56 条

[1] Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1 [J].

Alani, RM ;

Hasskarl, J ;

Grace, M ;

Hernandez, HC ;

Israel, MA ;

Münger, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) :9637-9641

[2] Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation [J].

Andersen, B ;

Weinberg, WC ;

Rennekampff, O ;

McEvilly, RJ ;

Bermingham, JR ;

Hooshmand, F ;

Vasilyev, V ;

Hansbrough, JF ;

Pittelkow, MR ;

Yuspa, SH ;

Rosenfeld, MG .

GENES & DEVELOPMENT, 1997, 11 (14) :1873-1884

[3] c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny [J].

Arnold, I ;

Watt, FM .

CURRENT BIOLOGY, 2001, 11 (08) :558-568

[4] Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo [J].

Balsitis, SJ ;

Sage, J ;

Duensing, S ;

Münger, K ;

Jacks, T ;

Lambert, PF .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (24) :9094-9103

[5] Role of the nude gene in epithelial terminal differentiation [J].

Baxter, RM ;

Brissette, JL .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 118 (02) :303-309

[6] The product of the mouse nude locus Whn, regulates the balance between epithelial cell growth and differentiation [J].

Brissette, JL ;

Li, J ;

Kamimura, J ;

Lee, D ;

Dotto, GP .

GENES & DEVELOPMENT, 1996, 10 (17) :2212-2221

[7] Contrasting localization of c-Myc with other Myc superfamily transcription factors in the human hair follicle and during the hair growth cycle [J].

Bull, JJ ;

Müller-Röver, S ;

Patel, SV ;

Chronnell, MT ;

McKay, IA ;

Philpott, MP .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 116 (04) :617-622

[8] Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled [J].

Chapellier, B ;

Mark, M ;

Messaddeq, N ;

Calléja, C ;

Warot, X ;

Brocard, J ;

Gérard, C ;

Li, M ;

Metzger, D ;

Ghyselinck, NB ;

Chambon, P .

EMBO JOURNAL, 2002, 21 (13) :3402-3413

[9] Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites [J].

Crawford, GE ;

Holt, IE ;

Mullikin, JC ;

Tai, D ;

Green, ED ;

Wolfsberg, TG ;

Collins, FS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (04) :992-997

[10] The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice [J].

Dai, X ;

Schonbaum, C ;

Degenstein, L ;

Bai, WY ;

Mahowald, A ;

Fuchs, E .

GENES & DEVELOPMENT, 1998, 12 (21) :3452-3463

← 1 2 3 4 5 6 →