The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

被引：9

作者：

Banno, R

Arima, H

Sato, I

Hayashi, M

Goto, M

Sugimura, Y

Murase, T

Oiso, Y

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Metab Dis, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nagoya Univ, Res Inst Environm Med, Dept Endocrinol & Metab, Div Mol & Cellular Adapat, Nagoya, Aichi 4648601, Japan

来源：

PEPTIDES | 2004年 / 25卷 / 08期

关键词：

melanocortin agonist; hyperphagia; obesity; insulin resistance; OLETF rats;

D O I：

10.1016/j.peptides.2004.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats. (C) 2004 Elsevier Inc. All rights reserved.

引用

收藏

页码：1279 / 1286

页数：8

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