Synthesis and bioactivities of novel piperidylpyrimidine derivatives: Inhibitors of tumor necrosis factor-alpha production

被引：9

作者：

Fujiwara, N ^{[1
]}

Fujita, H ^{[1
]}

Iwai, K ^{[1
]}

Kurimoto, A ^{[1
]}

Murata, S ^{[1
]}

Kawakami, H ^{[1
]}

机构：

[1] Sumitomo Pharmaceut Co Ltd, Res Ctr, Konohana Ku, Osaka 5540022, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)00227-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New piperidylpyrimidine derivatives, including quinazolines, were prepared, and their abilities to inhibit TNF-alpha production evaluated. Some compounds showed potent inhibitory activity in mouse macrophages stimulated with LPS. The synthesis and structure-activity relationships of these compounds are described. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1317 / 1320

页数：4

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