Techniques: Fruit flies as models for neuropharmacological research

被引：35

作者：

Manev, H ^{[1
]}

Dimitrijevic, N ^{[1
]}

Dzitoyeva, S ^{[1
]}

机构：

[1] Univ Illinois, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2003年 / 24卷 / 01期

关键词：

D O I：

10.1016/S0165-6147(02)00004-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An unlikely animal model is gaining popularity in neuropharmacological research: the 2-mm fruit fly (Drosophila melanogaster). Drugs have been administered to adult flies in their food and, more recently, via gasses and injections. Pharmacological tools have introduced behavioral alterations in Drosophila reminiscent of human behavior, rescued flies from gene-alteration-triggered neuropathologies, and triggered gene silencing. Combined, these methods hold promise for significant neuropharmacological advancement.

引用

页码：41 / 43

页数：3

共 20 条

[1] Circadian modulation of dopamine receptor responsiveness in Drosophila melanogaster [J].

Andretic, R ;

Hirsh, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1873-1878

[2]

Baier A, 2002, J EXP BIOL, V205, P1233

[3] Gene silencing by double-stranded RNA [J].

Carthew, RW .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (02) :244-248

[4] The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics [J].

Costa, E ;

Davis, J ;

Pesold, C ;

Tueting, P ;

Guidotti, A .

CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (01) :56-62

[5] Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster [J].

Drier, EA ;

Tello, MK ;

Cowan, M ;

Wu, P ;

Blace, N ;

Sacktor, TC ;

Yin, JCP .

NATURE NEUROSCIENCE, 2002, 5 (04) :316-324

[6] Intra-abdominal injection of double-stranded RNA into anesthetized adult Drosophila triggers RNA interference in the central nervous system [J].

Dzitoyeva, S ;

Dimitrijevic, N ;

Manev, H .

MOLECULAR PSYCHIATRY, 2001, 6 (06) :665-670

[7]

Giordano E, 2002, GENETICS, V160, P637

[8]

Heberlein U, 2000, ALCOHOL RES HEALTH, V24, P185

[9] Life extension in Drosophila by feeding a drug [J].

Kang, HL ;

Benzer, S ;

Min, KT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :838-843

[10] Pharmacological evidence for GABAergic regulation of specific behaviors in Drosophila melanogaster [J].

Leal, SM ;

Neckameyer, WS .

JOURNAL OF NEUROBIOLOGY, 2002, 50 (03) :245-261

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