Lack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Population

被引：31

作者：

Alp, Ebru ^{[1
]}

Menevse, Sevda ^{[1
]}

Tulmac, Murat ^{[2
]}

Kan, Derya ^{[3
]}

Yalcin, Ridvan ^{[4
]}

Erkan, Aycan F. ^{[5
]}

Cengel, Atiye ^{[4
]}

机构：

[1] Gazi Univ, Fac Med, Dept Med Biol & Genet, TR-06500 Ankara, Turkey

[2] Kirkkale Univ, Fac Med, Dept Cardiol, Kirikkale, Turkey

[3] Gazi Univ, Fac Med, Dept Med Genet, TR-06500 Ankara, Turkey

[4] Gazi Univ, Fac Med, Dept Cardiol, TR-06500 Ankara, Turkey

[5] Ufuk Univ, Dept Cardiol, Ankara, Turkey

来源：

DNA AND CELL BIOLOGY | 2009年 / 28卷 / 07期

关键词：

GELATINASE-B-GENE; MISSENSE GLU298ASP VARIANT; MYOCARDIAL-INFARCTION; MATRIX METALLOPROTEINASES; FUNCTIONAL POLYMORPHISM; RISK-FACTOR; 5'-FLANKING REGION; CHILEAN SUBJECTS; COMMON VARIANT; T-786C;

D O I：

10.1089/dna.2009.0866

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Polymorphic variants of genes encoding proteins involved in vascular remodeling may genetically diverge among different populations and play a role in the susceptibility to the coronary artery disease (CAD). MMP-9-1562 C/T (rs3918242), eNOS T-786C (rs2070744), and Glu298Asp (rs1799983) are among the most studied of these polymorphisms. The aim of this study was to determine the relationship between CAD and these polymorphisms in the Turkish population. The analysis included 146 CAD+ and 122 CAD- individuals. Genomic DNA was isolated from whole blood and genotyping was performed by the PCR-RFLP method. No significant associations were found between -1562 C/T (p=0.557), Glu298Asp (p=0.432), and -786 T/C (p=0.055) polymorphisms and CAD. The distribution of each haplotype also did not differ between CAD+ and the CAD- samples (p>0.05). The present investigation is the first to study an association between -1562 C/T polymorphism and CAD in the Turkish population. In conclusion, no appreciable differences between CAD+ and CAD- samples were found in terms of polymorphisms mentioned above.

引用

页码：343 / 350

页数：8

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