Identification of new allelic variants in the ovine prion protein (PrP) gene

被引：44

作者：

Kutzer, T

Pfeiffer, I

Brenig, B

机构：

[1] Tierarztl Inst, D-37073 Gottingen, Germany

[2] Univ Gottingen, Inst Vet Med, D-3400 Gottingen, Germany

来源：

JOURNAL OF ANIMAL BREEDING AND GENETICS | 2002年 / 119卷 / 04期

关键词：

D O I：

10.1046/j.1439-0388.2002.00335.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The association between scrapie and polymorphisms of the prion protein (PrP) gene was studied in 1108 German sheep of 33 different breeds. The aim of the investigation was the determination of the codons 136, 154 and 171 of the PrP gene, which are important for scrapie susceptibility. In addition to the published allelic variants ARR, ARQ, AHQ, ARH and VRQ, two novel, rare haplotypes (AHR and VRR) were found in the breeds of Texel, Nolana and Suffolk. A comparison of PrP genotype frequencies among the analysed different breeds revealed distinct variations. Breeds such as Texel showed a complex genotype distribution over 17 variants, while breeds such as Friesian Milk Sheep indicated only seven different genotypes.

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页码：201 / 208

页数：8

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