Synthesis and biological activities of NB-506 analogues modified at the glucose group

被引：34

作者：

Ohkubo, M ^{[1
]}

Nishimura, T ^{[1
]}

Kawamoto, H ^{[1
]}

Nakano, M ^{[1
]}

Honma, T ^{[1
]}

Yoshinari, T ^{[1
]}

Arakawa, H ^{[1
]}

Suda, H ^{[1
]}

Morishima, H ^{[1
]}

Nishimura, S ^{[1
]}

机构：

[1] Merck Res Labs, Banyu Tsukuba Res Inst, Ibaraki, Osaka 3002611, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)00004-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new indolocarbazole compound, NB-506 (1). modified at the glucose group yielded a beta-D-glucopyranoside, J-107,088 (2), which showed potent anticancer activity. A beta-D-ribofuranoside, J-109,534 (3), was found to be 6 limes more potent than J-107,088 at inhibiting topoisomerase I. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：419 / 422

页数：4

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