HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection

被引：927

作者：

Khakoo, SI

Thio, CL

Martin, MP

Brooks, CR

Gao, XJ

Astemborski, J

Cheng, J

Goedert, JJ

Vlahov, D

Hilgartner, M

Cox, S

Little, AM

Alexander, GJ

Cramp, ME

O'Brien, SJ

Rosenberg, WMC

Thomas, DL

Carrington, M ^{[1
]}

机构：

[1] Univ Southampton, Div Infect Inflammat & Repair, Liver Grp, Southampton 5016 6YD, Hants, England

[2] Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21231 USA

[3] NCI Federick, Basic Res Program, Sci Applicat Int Corp Frederick Inc, Lab Gen Divers, Frederick, MD 21702 USA

[4] NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20852 USA

[5] New York Acad Med, New York, NY 10029 USA

[6] Cornell Med Ctr, New York Presbyterian Hosp, Dept Pediat, New York, NY 10021 USA

[7] Royal Free Hosp, Anthony Nolan Res Inst, London NW3 2PF, England

[8] Univ Cambridge, Dept Med, Cambridge CD2 2QQ, England

[9] Derriford Hosp, Dept Gastroenterol, Plymouth PL6 8DH, Devon, England

[10] NCI, Lab Gen Divers, Frederick, MD 21702 USA

来源：

SCIENCE | 2004年 / 305卷 / 5685期

关键词：

D O I：

10.1126/science.1097670

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.

引用

页码：872 / 874

页数：3

共 23 条

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Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors [J].