Resistance mechanisms in an in vitro-selected amoxicillin-resistant strain of Helicobacter pylori

被引：42

作者：

Co, Edgie-Mark A. ^{[1
]}

Schiller, Neal L. ^{[1
]}

机构：

[1] Univ Calif Riverside, Div Biomed Sci, Riverside, CA 92521 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 12期

关键词：

D O I：

10.1128/AAC.00759-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

We investigated the beta-lactam resistance mechanism(s) of an in vitro-selected amoxicillin-resistant Helicobacter pylori strain (AmoxR). Our results demonstrated that resistance is due to a combination of amino acid substitutions in penicillin binding protein I (PBP1), HopB, and HopC identified in AmoxR, resulting in decreased affinity of PBP1 for amoxicillin and decreased accumulation of penicillin.

引用

页码：4174 / 4176

页数：3

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