Tamsulosin 0.4 mg once daily: Tolerability in older and younger patients with lower urinary tract symptoms suggestive of benign prostatic obstruction (symptomatic BPH)

被引:49
作者
Chapple, CR
Baert, L
Thind, P
Hofner, K
Khoe, GSS
Spangberg, A
机构
[1] UNIV ZIEKENHUIS GASTHUISBERG,LOUVAIN,BELGIUM
[2] FREDERIKSBERG UNIV HOSP,FREDERIKSBERG,DENMARK
[3] HANNOVER MED SCH,HANNOVER,GERMANY
[4] MED SPECTRUM TWENTE,ENSCHEDE,NETHERLANDS
[5] LINKOPING UNIV HOSP,S-58185 LINKOPING,SWEDEN
关键词
benign prostatic obstruction; tamsulosin; alpha-adrenoceptor antagonists; lower urinary tract symptoms; tolerability; older and younger patients;
D O I
10.1159/000480808
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To compare the safety and tolerability of tamsulosin 0.4 mg once daily in younger (<65 years) and older (greater than or equal to 65 years) patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO), Methods: In a retrospective analysis of two European double-blind, randomized, placebo-controlled trials, safety was assessed in 574 younger or older patients treated with tamsulosin or placebo for 12 weeks. Results: The incidence of adverse events, drug-related adverse events, serious adverse events and discontinuations due to adverse events was similar in older and younger tamsulosin-treated patients and was not significantly different from placebo. Although abnormal ejaculation was slightly more common in younger than older men receiving tamsulosin, the difference was not statistically significant from the placebo groups in both age groups. The incidence of adverse events possibly associated with vasodilation in tamsulosin-treated younger and older patients was 8.4 and 4.2%, respectively; these were comparable with the values for placebo-treated patients: 7.5 and 6%, respectively, Baseline systolic blood pressure was higher in older than younger patients, but there were minimal changes in blood pressure or pulse rate in tamsulosin- or placebo-treated patients in either age group, Conclusions: Tamsulosin is well tolerated and suitable for use in older and younger patients with LUTS suggestive of BPO (symptomatic BPH).
引用
收藏
页码:462 / 470
页数:9
相关论文
共 40 条
[1]   TAMSULOSIN, A SELECTIVE ALPHA(1C)-ADRENOCEPTOR ANTAGONIST - A RANDOMIZED, CONTROLLED TRIAL IN PATIENTS WITH BENIGN PROSTATIC OBSTRUCTION (SYMPTOMATIC BPH) [J].
ABRAMS, P ;
SCHULMAN, CC ;
VAAGE, S ;
ABEL, P ;
BAXBY, K ;
BOEMINGHAUS, F ;
DELAERE, KPJ ;
DENIS, L ;
DIJKMAN, GA ;
HASSELLUND, S ;
HOHENFELLNER, R ;
JANKNEGT, RA ;
KAPPER, BJ ;
KARTHAUS, HFM ;
KHOE, GSS ;
KIL, PJM ;
KROMANNANDERSEN, B ;
LELIEFELD, HHJ ;
LOCK, TMTW ;
MOHR, M ;
MOMMSEN, S ;
OGREID, P ;
OTTO, RW ;
PLASMAN, JWMH ;
PULL, HC ;
RYTTOV, N ;
TOLLEY, DA ;
VENEMA, PL ;
WYNDAELE, JJ ;
YPMA, AFGVM .
BRITISH JOURNAL OF UROLOGY, 1995, 76 (03) :325-336
[2]   MANAGING LOWER URINARY-TRACT SYMPTOMS IN OLDER MEN [J].
ABRAMS, P .
BRITISH MEDICAL JOURNAL, 1995, 310 (6987) :1113-1117
[3]   THE DEVELOPMENT OF HUMAN BENIGN PROSTATIC HYPERPLASIA WITH AGE [J].
BERRY, SJ ;
COFFEY, DS ;
WALSH, PC ;
EWING, LL .
JOURNAL OF UROLOGY, 1984, 132 (03) :474-479
[4]  
Boyarsky S, 1976, Trans Am Assoc Genitourin Surg, V68, P29
[5]  
BUZELIN JM, 1997, IN PRESS BR J UROL
[6]  
CAINE M, 1990, UROL CLIN N AM, V17, P641
[7]   A 12-WEEK PLACEBO-CONTROLLED DOUBLE-BLIND-STUDY OF PRAZOSIN IN THE TREATMENT OF PROSTATIC OBSTRUCTION DUE TO BENIGN PROSTATIC HYPERPLASIA [J].
CHAPPLE, CR ;
STOTT, M ;
ABRAMS, PH ;
CHRISTMAS, TJ ;
MILROY, EJG .
BRITISH JOURNAL OF UROLOGY, 1992, 70 (03) :285-294
[8]   ALPHA(1)-ADRENOCEPTOR SUBTYPES IN THE HUMAN PROSTATE [J].
CHAPPLE, CR ;
BURT, RP ;
ANDERSSON, PO ;
GREENGRASS, P ;
WYLLIE, M ;
MARSHALL, I .
BRITISH JOURNAL OF UROLOGY, 1994, 74 (05) :585-589
[9]  
Chapple CR, 1996, EUR UROL, V29, P155
[10]  
Chapple CR, 1996, EUR UROL, V29, P129