Sematilide blocks the inward rectifier potassium channel in isolated guinea pig ventricular myocytes

被引：3

作者：

Takai, H

Sato, R

Katori, R

机构：

[1] First Dept. of Internal Medicine, Kinki University School of Medicine

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1997年 / 28卷 / 05期

关键词：

inward rectifier potassium channel; sematilide; ventricular myocyte;

D O I：

10.1016/S0306-3623(96)00301-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. In whole cell patch recording, the relative potency of the blocking action of sematilide on I-K1 was found to be constant at. each potential level of I-K1 activation. Under more acidic condition, the degree of block was decreased. These results strongly suggested that the neutral form of sematilide may penetrate the cardiac cell membrane via hydrophobic pathway. 2. In cell-attached patches, sematilide prolonged the interburst interval and reduced the opening probabilities of the I-K1 channel without affecting either the mean open time or the mean closed time within a burst. (C) 1997 Elsevier Science Inc.

引用

页码：665 / 670

页数：6

共 22 条

[1]

[Anonymous], 1989, NEW ENGL J MED, V321, P406

[2]

ANTONACCIO MJ, 1990, AM J CARDIOL, V65, pA12

[3] CELLULAR ELECTROPHYSIOLOGICAL EFFECTS OF THE CLASS-III ANTIARRHYTHMIC AGENTS SEMATILIDE AND CLOFILIUM ON RABBIT ATRIAL TISSUES [J].