Photo-crosslinkable PEG-Based Microribbons for Forming 3D Macroporous Scaffolds with Decoupled Niche Properties

被引:29
作者
Han, Li-Hsin [1 ]
Tong, Xinming [1 ]
Yang, Fan [1 ,2 ]
机构
[1] Stanford Univ, Dept Orthopaed Surg, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
关键词
scaffolds; microribbons; tissue engineering; biomedical applications; TISSUE ENGINEERING SCAFFOLDS; EXTRACELLULAR MICROENVIRONMENTS; STEM-CELLS; HYDROGELS; DIFFERENTIATION; BIOMATERIALS; FABRICATION; ELASTOMERS; SUBSTRATE; KINETICS;
D O I
10.1002/adma.201304805
中图分类号
O6 [化学];
学科分类号
070301 [无机化学];
摘要
PEG-based microribbons are designed and fabricated as building blocks for constructing a 3D cell niche with independently tunable biochemical, mechanical, and topographical cues. This platform supports direct cell encapsulation, allows spatial patterning of biochemical cues, and may provide a valuable tool for facilitating the analyses of how interactive niche signaling regulates cell fate in three dimensions. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:1757 / 1762
页数:6
相关论文
共 34 条
[1]
Adam S. S., 2006, CELL, V126, P677
[2]
Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells [J].
Benoit, Danielle S. W. ;
Schwartz, Michael P. ;
Durney, Andrew R. ;
Anseth, Kristi S. .
NATURE MATERIALS, 2008, 7 (10) :816-823
[3]
Engineered Microenvironments for Controlled Stem Cell Differentiation [J].
Burdick, Jason A. ;
Vunjak-Novakovic, Gordana .
TISSUE ENGINEERING PART A, 2009, 15 (02) :205-219
[4]
Callister W D., 2018, Materials Science and Engineering: An Introduction, V10th edn
[5]
Aligned protein-polymer composite fibers enhance nerve regeneration: A potential tissue-engineering platform [J].
Chew, Sing Yian ;
Mi, Ruifa ;
Hoke, Ahmet ;
Leong, Kam W. .
ADVANCED FUNCTIONAL MATERIALS, 2007, 17 (08) :1288-1296
[6]
Taking cell-matrix adhesions to the third dimension [J].
Cukierman, E ;
Pankov, R ;
Stevens, DR ;
Yamada, KM .
SCIENCE, 2001, 294 (5547) :1708-1712
[7]
Nuclear actin and myosins: Life without filaments [J].
de Lanerolle, Primal ;
Serebryannyy, Leonid .
NATURE CELL BIOLOGY, 2011, 13 (11) :1282-1288
[8]
Peptide-Functionalized Click Hydrogels with Independently Tunable Mechanics and Chemical Functionality for 3D Cell Culture [J].
DeForest, Cole A. ;
Sims, Evan A. ;
Anseth, Kristi S. .
CHEMISTRY OF MATERIALS, 2010, 22 (16) :4783-4790
[9]
DeForest CA, 2009, NAT MATER, V8, P659, DOI [10.1038/NMAT2473, 10.1038/nmat2473]
[10]
Tissue cells feel and respond to the stiffness of their substrate [J].
Discher, DE ;
Janmey, P ;
Wang, YL .
SCIENCE, 2005, 310 (5751) :1139-1143