Self-aggregation of reverse bis peptide conjugate derived from the unstructured region of the prion protein

被引：39

作者：

Madhavaiah, C ^{[1
]}

Verma, S ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 06期

关键词：

D O I：

10.1039/b316793c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel his scaffold containing a pentapeptide PHGGG, derived from the prion octarepeat, forms fibrils of nanometric dimensions, thus indicating that certain segments in the unstructured region of the prion protein may facilitate an initial fibrillation event.

引用

页码：638 / 639

页数：2

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