The gatekeepers of mitochondrial calcium influx: MICU1 and MICU2

被引：38

作者：

Ahuja, Malini ^{[1
]}

Muallem, Shmuel ^{[1
]}

机构：

[1] NIDCR, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA

来源：

EMBO REPORTS | 2014年 / 15卷 / 03期

关键词：

UNIPORTER;

D O I：

10.1002/embr.201438446

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The receptor-evoked Ca2+ signal is sensed and translated by mitochondria. Physiological cytoplasmic Ca2+ ([Ca2+](c)) oscillations result in mitochondrial Ca2+ ([Ca2+](m)) oscillations, while large and sustained [Ca2+](c) increase results in a pathologic increase in basal [Ca2+](m) and in Ca2+ accumulation. The physiological [Ca2+](m) signal regulates [Ca2+](c) and stimulates oxidative metabolism, while excess Ca2+ accumulation causes cell stress leading to cell death. [Ca2+](m) is determined by Ca2+ uptake mediated by the mitochondria Ca2+ uniporter (MCU) channel and by Na+- and H+-coupled Ca2+ extrusion .

引用

页码：205 / 206

页数：2

共 10 条

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