Photoresponsive cAMP signal transduction in cyanobacteria

被引:40
作者
Ohmori, M [1 ]
Okamoto, S [1 ]
机构
[1] Univ Tokyo, Grad Sch Arts & Sci, Dept Life Sci Biol, Tokyo 1538902, Japan
关键词
D O I
10.1039/b401623h
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The molecular mechanism of cAMP-mediated signal transduction from light reception to the physiological response via regulation of gene expression in cyanobacteria is described based on our recent works. Cyanobacteria are known as the organisms that acquired oxygen-evolving, higher plant type photosynthesis. We have found that the cellular cAMP level in the filamentous cyanobacteria Anabaena was oppositely regulated by red and far-red light, i.e., decreasing and increasing, respectively, suggesting that a phytochrome-like red/far-red photoreversible pigment regulates the activity of a certain adenylate cyclase. On the other hand, in the unicellular cyanobacterium Synechocystis cellular cAMP content was increased by blue light irradiation, which led to stimulation of cell motility. The cAMP signaling pathway is known to play an important role in the regulation of various biological activities by altering enzyme activities or controlling gene expression levels in both prokaryotes and eukaryotes. We have isolated genes for adenylate cyclases and cAMP receptor proteins and characterized their molecular properties. Disruption of these genes resulted in the loss of cell motility. It is concluded that the light signal was transmitted by cAMP signal cascade in cyanobacteria.
引用
收藏
页码:503 / 511
页数:9
相关论文
共 98 条
  • [1] SITE OF CA2+ ACTION IN TRIGGERING MOTILITY IN THE CYANOBACTERIUM SPIRULINA SUBSALSA
    ABELIOVICH, A
    GAN, J
    [J]. CELL MOTILITY AND THE CYTOSKELETON, 1982, 2 (04): : 393 - 403
  • [2] The GAF domain: an evolutionary link between diverse phototransducing proteins
    Aravind, L
    Ponting, CP
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (12) : 458 - 459
  • [3] Type IV pilus biogenesis and motility in the cyanobacterium Synechocystis sp PCC6803
    Bhaya, D
    Bianco, NR
    Bryant, D
    Grossman, A
    [J]. MOLECULAR MICROBIOLOGY, 2000, 37 (04) : 941 - 951
  • [4] The role of an alternative sigma factor in motility and pilus formation in the cyanobacterium Synechocystis sp. strain PCC6803
    Bhaya, D
    Watanabe, N
    Ogawa, T
    Grossman, AR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) : 3188 - 3193
  • [5] CYCLIC-AMP IN PROKARYOTES
    BOTSFORD, JL
    HARMAN, JG
    [J]. MICROBIOLOGICAL REVIEWS, 1992, 56 (01) : 100 - 122
  • [6] ATP POOLS AND TRANSIENTS IN BLUE-GREEN-ALGA, ANABAENA-CYLINDRICA
    BOTTOMLEY, PJ
    STEWART, WDP
    [J]. ARCHIVES OF MICROBIOLOGY, 1976, 108 (03) : 249 - 258
  • [7] A single flavoprotein, AppA, integrates both redox and light signals in Rhodobacter sphaeroides
    Braatsch, S
    Gomelsky, M
    Kuphal, S
    Klug, G
    [J]. MOLECULAR MICROBIOLOGY, 2002, 45 (03) : 827 - 836
  • [8] An abundant cell-surface polypeptide is required for swimming by the nonflagellated marine cyanobacterium Synechococcus
    Brahamsha, B
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) : 6504 - 6509
  • [9] The phototropin family of photoreceptors
    Briggs, WR
    Beck, CF
    Cashmore, AR
    Christie, JM
    Hughes, J
    Jarillo, JA
    Kagawa, T
    Kanegae, H
    Liscum, E
    Nagatani, A
    Okada, K
    Salomon, M
    Rüdiger, W
    Sakai, T
    Takano, M
    Wada, M
    Watson, JC
    [J]. PLANT CELL, 2001, 13 (05) : 993 - 997
  • [10] DIFFERENTIAL ACTIVATION OF YEAST ADENYLATE-CYCLASE BY WILD-TYPE AND MUTANT RAS PROTEINS
    BROEK, D
    SAMIY, N
    FASANO, O
    FUJIYAMA, A
    TAMANOI, F
    NORTHUP, J
    WIGLER, M
    [J]. CELL, 1985, 41 (03) : 763 - 769