Autophagy and the Immune Response to TB

被引：41

作者：

Harris, J. ^{[1
]}

Hope, J. C. ^{[2
]}

Lavelle, E. C.

机构：

[1] Trinity Coll Dublin, Dept Biochem & Immunol, Adjuvant Res Grp, Sch Biochem & Immunol, Dublin 2, Ireland

[2] Inst Anim Hlth, Compton, Berks, England

来源：

TRANSBOUNDARY AND EMERGING DISEASES | 2009年 / 56卷 / 6-7期

基金：

爱尔兰科学基金会;

关键词：

innate immunity; phagosome maturation; cytokines; inflammasome; Irgm1; CLASS-II MOLECULES; MYCOBACTERIUM-TUBERCULOSIS; INTRACELLULAR MYCOBACTERIA; HUMAN MACROPHAGES; HUMAN MONOCYTES/MACROPHAGES; INFLAMMASOME ACTIVATION; CONTAINING PHAGOSOMES; ANTIGEN PRESENTATION; TOXOPLASMA-GONDII; DEFENSE-MECHANISM;

D O I：

10.1111/j.1865-1682.2009.01069.x

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

P>Autophagy is a homeostatic mechanism for the catabolism of cytosolic constituents, including organelles, in times of stress and nutrient deprivation. In addition, autophagy has been linked to innate and adaptive immune responses to numerous infectious microorganisms, including mycobacteria. This review explores the role of autophagy in the responses of antigen-presenting cells to mycobacteria, including links with phagosome maturation, inflammasome activation and antigen presentation. In addition, the modulation of autophagy by cytokines and pathogen-derived stimuli is discussed.

引用

页码：248 / 254

页数：7

共 69 条

[1]

AHLBERG J, 1982, LAB INVEST, V47, P523

[2]

Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy [J].

Alonso, Sylvie ;

Pethe, Kevin ;

Russell, David G. ;

Purdy, Georgiana E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (14) :6031-6036

[3]

CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes [J].

Andrade, Rosa M. ;

Wessendarp, Matthew ;

Gubbels, Marc-Jan ;

Striepen, Boris ;

Subauste, Carlos S. .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (09) :2366-2377

[4]

The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway [J].

Arico, S ;

Petiot, A ;

Bauvy, C ;

Dubbelhuis, PF ;

Meijer, AJ ;

Codogno, P ;

Ogier-Denis, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (38) :35243-35246

[5]

ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages [J].

Biswas, Debasis ;

Qureshi, Omar S. ;

Lee, Wing-Yiu ;

Croudace, Joanne E. ;

Mura, Manuela ;

Lammas, David A. .

BMC IMMUNOLOGY, 2008, 9 (1)

[6]

Excessive degradation of intracellular protein in macrophages prevents presentation in the context of major histocompatibility complex class II molecules [J].

Brazil, MI ;

Weiss, S ;

Stockinger, B .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (06) :1506-1514

[7]

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages [J].

Cruz, Cristiane M. ;

Rinna, Alessandra ;

Forman, Henry Jay ;

Ventura, Ana L. M. ;

Persechini, Pedro M. ;

Ojcius, David M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (05) :2871-2879

[8]

Toll-like receptors control autophagy [J].

Delgado, Monica A. ;

Elmaoued, Rasha A. ;

Davis, Alexander S. ;

Kyei, George ;

Deretic, Vojo .

EMBO JOURNAL, 2008, 27 (07) :1110-1121

[9]

Autophagy promotes MHC class II presentation of peptides from intracellular source proteins [J].

Dengjel, J ;

Schoor, O ;

Fischer, R ;

Reich, M ;

Kraus, M ;

Müller, M ;

Kreymborg, K ;

Altenberend, F ;

Brandenburg, J ;

Kalbacher, H ;

Brock, R ;

Driessen, C ;

Rammensee, HG ;

Stevanovic, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (22) :7922-7927

[10]

Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism [J].

Deretic, V ;

Singh, S ;

Master, S ;

Harris, J ;

Roberts, E ;

Kyei, G ;

Davis, A ;

de Haro, S ;

Naylor, J ;

Lee, HH ;

Vergne, I .

CELLULAR MICROBIOLOGY, 2006, 8 (05) :719-727

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