Non-erythroid effects of erythropoietin: Are neutrophils a target?

被引：12

作者：

Avneon, Malayan ^{[1
]}

Lifshitz, Lilach ^{[1
]}

Katz, Odelia ^{[1
]}

Prutchi-Sagiv, Sara ^{[1
]}

Gassmann, Max ^{[3
,4
]}

Mittelman, Moshe ^{[2
]}

Neumann, Drorit ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Dept Cell & Dev Biol, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Sourasky Med Ctr, Dept Med A, IL-64239 Tel Aviv, Israel

[3] Univ Zurich, Inst Vet Physiol, Vetsuisse Fac, CH-8057 Zurich, Switzerland

[4] Zurich Ctr Integrat Human Physiol ZIHP, CH-8057 Zurich, Switzerland

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 10期

关键词：

Erythropoietin; Neutrophils; Inflammation; Murine models; IMMUNE-RESPONSES; MYELOMA;

D O I：

10.1016/j.leukres.2009.03.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We have previously shown that erythropoietin (EPO) potentiates the immune response. Analysis of various possible cellular mediators was performed on EPO-injected mice and transgenic mice overexpressing human EPO (tg6). Here we present our studies on neutrophils, peritoneal (casein induced), and from the peripheral blood, spleen and bone marrow. Neutrophil counts were elevated in peripheral blood and spleens of the tg6 mice, yet, no other EPO-associated effects were detected in the count and function of the different neutrophil populations. Hence, neutrophils are probably not mediators of the EPO immunological effects, although their counts may be affected by extreme EPO levels. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1430 / 1432

页数：3

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